Results 261 to 270 of about 1,659,433 (349)

Community perspectives on Exception from Informed Consent (EFIC) in the intensive care unit (ICU) setting: a mixed methods study. [PDF]

open access: yesBMJ Public Health
Keijer BL   +9 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

LGBTQ+ individuals' experiences of initial identity disclosure in primary healthcare services: a qualitative scoping review. [PDF]

open access: yesInt J Nurs Stud Adv
Tsiokanou P   +5 more
europepmc   +1 more source

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