Results 201 to 210 of about 591,464 (366)

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

Machine Learning-Based Prediction of Early Patient-Controlled Analgesia Discontinuation After Total Knee Arthroplasty: A Retrospective Cohort Study. [PDF]

J Clin Med
Kwak SG, Kwon JB, Choi WK.
europepmc   +1 more source

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

Factors involved in the discontinuation of oral intake in elderly patients with recurrent aspiration pneumonia: a multicenter study

, 2017
Tsuneaki Kenzaka,1,2 Taro Takeshima,3 Koki Kosami,2 Ayako Kumabe,2 Yuki Ueda,2 Takeshi Takahashi,4 Yuya Yamamoto,5 Yurika Hayashi,5 Akihito Kitao,5 Masanobu Okayama6 1Division of Community Medicine and Career Development, Kobe University Graduate School
Takahashi T, Hayashi Y, Okayama M, Kumabe A, Kitao A, Yamamoto Y, Kosami K, Takeshima T, Ueda Y, Kenzaka T   +9 more
core  

Genotype influences antidepressant discontinuation in a pre-emptive pharmacogenetic testing population. [PDF]

Pharmacogenomics J
Baye JF, Petry NJ, Hines L, Weaver M, Reinke M, Brady H, Massmann A, Schultz A.   +7 more
europepmc   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Artificial Intelligence Discontinuation Effects (AI-DICE): An Emerging Phenomenon in Mental Health Applications. [PDF]

JMIR AI
Kelly MM, Moore PS, Zai AH, Allison J.
europepmc   +1 more source

Clinical Features of 24 Patients With Rebound‐Associated Vertebral Fractures After Denosumab Discontinuation: Systematic Review and Additional Cases

Journal of Bone and Mineral Research, 2017
A. Anastasilakis, S. Polyzos, P. Makras, B. Aubry-Rozier, Stella Kaouri, O. Lamy   +5 more
semanticscholar   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Reasons for discontinuation of GLP1 receptor agonists: data from a real-world cross-sectional survey of physicians and their patients with type 2 diabetes

, 2017
Mirko V Sikirica,1 Alan A Martin,2 Robert Wood,3 Andrea Leith,3 James Piercy,3 Victoria Higgins3 1Value Evidence and Outcomes, GlaxoSmithKline, Collegeville, PA, USA; 2Value Evidence and Outcomes, GlaxoSmithKline, London, UK; 3Diabetes, Adelphi Real ...
Leith A, Higgins V, Wood R, Piercy J, Sikirica MV, Martin AA   +5 more
core