Results 151 to 160 of about 18,549 (299)

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

open access: yesAdvanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng   +13 more
wiley   +1 more source

Optimal partial regularity for quasilinear elliptic systems with VMO coefficients based on A-harmonic approximations

open access: yesElectronic Journal of Differential Equations, 2015
In this article, we consider quasi-linear elliptic systems in divergence form with discontinuous coefficients under controllable growth. We establish an optimal partial regularity of the weak solutions by a modification of A-harmonic approximation ...
Haiyan Yu, Shenzhou Zheng
doaj  

Estimation of discontinuous coefficients and boundary parameters for hyperbolic systems

open access: yes, 1986
The problem of estimating discontinuous coefficients, including locations of discontinuities, that occur in second order hyperbolic systems typical of those arising in I-D surface seismic problems is discussed.
Lamm, P. K., Murphy, K. A.
core  

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

open access: yesAdvanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao   +7 more
wiley   +1 more source

Integral Transforms with Non-separated Variables and Discontinuous Coefficients

open access: yes, 2013
Multidimensional integral transforms with non-separated variables for discontinuous coefficients problems are constructed in the case where the coefficient discontinuities are on the parallel hyperplanes.
Yaremko, O.E.
core   +1 more source

On some regularity and nonregularity results for solutions to parabolic systems

open access: yesLe Matematiche, 2000
A short survey of recent results on smoothness of weak solutions to parabolic systems with nonsmooth coefficients in olane is given. Moreover, for space dimensions n\ge 3 and any closed subset F in R^n we construct a linear parabolic system with bounded ...
Jana Stará, Oldřich John
doaj  

Tunable Negative Thermal Expansion in Fe/Cr‐Substituted Nd2Co17 Compounds via Magnetoelastic Coupling

open access: yesAdvanced Science, EarlyView.
This study achieves anisotropic thermal expansion tuning in Nd2(Co1‐xFex)17‐yCry compounds via a magnetoelastic strategy. Variable‐temperature synchrotron X‐ray diffraction reveals that increased Fe content induces switchable lattice responses. Compositional control reduces the volume expansion coefficient αV by 20% (x═0.7) and modulates TC (442–625 K),
Jiayuan Li   +8 more
wiley   +1 more source

Architected Inverse Nacre Hydrogels With High Strength and Crack‐Insensitive Toughness

open access: yesAdvanced Science, EarlyView.
Hydrogels hold promise for biomedical and engineering applications, yet their practical use is fundamentally limited by the strength‐toughness trade‐off and poor fatigue resistance. In this study, a bioinspired inverse nacre architecture constructed via a scalable thermo‐calendering process is introduced, which overcomes these classic limitations ...
Haidi Wu   +10 more
wiley   +1 more source

Third-order operator-differential equations with discontinuous coefficients and operators in the boundary conditions

open access: yesElectronic Journal of Differential Equations, 2013
We study a third-order operator-differential equation on the semi-axis with a discontinuous coefficient and boundary conditions which include an abstract linear operator.
Araz R. Aliev, Nazila L. Muradova
doaj  

Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing

open access: yesAdvanced Science, EarlyView.
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos   +17 more
wiley   +1 more source

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