Results 161 to 170 of about 90,682 (248)

Copula‐based joint modelling of emergency department visits with time‐varying dependence

Canadian Journal of Statistics, EarlyView.
Abstract Jointly modelling multiple correlated count time series is essential in health services research, where outcomes like emergency visits for mental health and substance use often evolve together. Ignoring these dependencies can obscure meaningful trends and limit the effectiveness of policy evaluation.
Guanjie Lyu, Cindy Feng, Lihui Liu
wiley   +1 more source

Interobserver Variability in Lung-RADS Categorization Between Tertiary and Non-Tertiary Hospitals, and Its Implications for Patient Management. [PDF]

J Clin Med
Kim YN, You S, Sun JS, Park KJ, Park S, Han T, Sur YK.   +6 more
europepmc   +1 more source

Estimated glomerular filtration rate discordance and cardiopulmonary morbidity in sickle cell disease. [PDF]

Blood Adv
Olaniran KO, Nero AC, Toto RD.
europepmc   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Correction to "Biogeographic Structure and Mitonuclear Discordance Reveal Cryptic Diversity in Pacific Herring (<i>Clupea pallasii</i>)". [PDF]

Ecol Evol
europepmc   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, EarlyView.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

SOFA-2 reclassification: data availability and incremental prognostic value. [PDF]

Crit Care
Kuzukıran Kocataş D.
europepmc   +1 more source

Physiology‐Guided Drug‐Coated Balloon Angioplasty: What We Know and What is Yet to be Understood

Catheterization and Cardiovascular Interventions, EarlyView.
Marco Frazzetto, Filippo Luca Gurgoglione, Bharat Khialani, Sandeep Basavarajaiah, Bernardo Cortese   +4 more
wiley   +1 more source

Characterization of NAT2 Using Long‐Read Sequencing: Allele, Diplotype, and Phenotype Call Accuracy Compared to Other Testing Strategies

Clinical Pharmacology &Therapeutics, EarlyView.
The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
Shobana John, Erin C. Boone, Byunggil Yoo, Laura B. Ramsey, Andrea Gaedigk   +4 more
wiley   +1 more source

Post-transplant diabetes mellitus in kidney transplant recipients: insights from continuous glucose monitoring. [PDF]

Clin Kidney J
Oweidat K, Farmer CK.
europepmc   +1 more source