Results 71 to 80 of about 90,682 (248)

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

A multisite validation of whole slide imaging for primary diagnosis using standardized data collection and analysis

Journal of Pathology Informatics, 2016
Context: Text-based reporting and manual arbitration for whole slide imaging (WSI) validation studies are labor intensive and do not allow for consistent, scalable, and repeatable data collection or analysis. Objective: The objective of this study was to
Katy Wack, Laura Drogowski, Murray Treloar, Andrew Evans, Jonhan Ho, Anil Parwani, Michael C Montalto   +6 more
doaj   +1 more source

Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor‐Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment

Advanced Science, EarlyView.
This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang, Zijing Liu, Xiangyue Meng, Pengjun Jiang, Jie Qu, Yu Jiang, Binxu Qiu, Jie Chen, Piaopiao Chen   +8 more
wiley   +1 more source

Narrative Unreliability as a Literary Device and Reception Shift

Pitannâ Lìteraturoznavstva, 2019
The primary aim of the article is to gain a better understanding of narrative unreliability as a literary device in reception perspective. While previous studies have focused mainly on textual incongruities, argued for an encoded strategy on the part of
Aliona Matiychak
doaj   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Diagnosis of Immunodeficiency Presenting as ABO Grouping Discrepancy: Two Case Reports

Journal of Applied Hematology
The correct determination of ABO grouping is of paramount importance in blood transfusion. The concordance between forward grouping and the reverse grouping tests ensures the validation of blood grouping and transfusion safety.
Nabiha Trougouty, Amjad Idrissi, Rachid Seddik, Abderrahime Bouali   +3 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Optimizing Pre‐Operative Clinical Staging in Resectable Non‐Small Cell Lung Cancer (NSCLC): A Retrospective Cohort Study

Thoracic Cancer
Background Accurate pre‐operative clinical staging is essential for guiding treatment in resectable non‐small cell lung cancer (NSCLC). Discrepancies between clinical and pathological staging raise concerns about treatment appropriateness.
E. Samuel, C. Thomas, C. Thompson, E. Paul, M. Cherk, S. Ellis, M. Siemienowicz, S. Tissera, U. Samankula, S. Scholz, L. Zhang, J. Grewal, J. Cox, C. Yu, G. Adabi, D. Keating, J. Taverner, J. Gooi, S. Wayne, J. Zalcberg, R. G. Stirling   +20 more
doaj   +1 more source

Analysis of the Course of Action in Practices

Contratexto, 2016
This is a semiotic essay in which the production of meaning is analyzed during the course of action. As it is an opened course, its nature and projective scope are relevant,whichplacesus inthe actionfieldas language, and also in the syntagmatic settings ...
Jacques Fontanille
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source