Results 41 to 50 of about 11,548,225 (392)
Jurnal Teknik SipilBetter Value for Money (VFM) is a key reason The Government opts for Public-Private Partnership (PPP) schemes in infrastructure project delivery.
Andreas Wibowo
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The practice of discounting in economic evaluations of healthcare interventions [PDF]
, 2001 Objectives: Discounting of costs in health-related economic evaluation is generally regarded as uncontroversial, but there is disagreement about discounting health benefits. We sought to explore the current recommendations and practice in health economic
Gravelle, H., Smith, D.H.
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Domain-specific temporal discounting and temptation [PDF]
Judgment and Decision Making, 2010 In this investigation, we test whether temporal discounting is domain-specific (i.e., compared to other people, can an individual have a relatively high discount rate for one type of reward but a relatively low discount rate for another?), and we examine
Eli Tsukayama, Angela Lee Duckworth
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High discount rates by private actors undermine climate change adaptation policies
Climate Risk Management, 2023 Adaptation requires investing now to avoid future damages, and thus adaptation is shaped by discount rates. Although the role of social discount rates in climate policy design has been well documented, the role of private discount rates has been ignored.
Francisco Alpizar +3 more
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Accommodating energy price volatility in life cycle cost analysis of asphalt pavements
Journal of Civil Engineering and Management, 2016 Energy price is related to more than half of the total life cycle cost of asphalt pavements. Furthermore, the fluctuation related to price of energy has been much higher than the general inflation and interest rate.
Iman Mirzadeh, Bjorn Birgisson
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Energy Reports, 2020 With a great reduction in the cost of rooftop photovoltaic systems (PVs), many new business models of PVs and the behind-the-meter scheme (BTMS) have been launched, especially the solar power purchase agreement (SPPA).
Chawin Prapanukool, Surachai Chaitusaney
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Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
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Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source