Results 141 to 150 of about 1,176,874 (306)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Discourse Tagging Tool and Discourse-Tagged Multilingual Corpora

, 1994
As a part of our on-going research on multilingual anaphora resolution (cf. Aone and McKee [3], Aone [1]), we have built a graphical tool to tag texts with antecedent-anaphor relations and have created corpora tagged with such relations. The tool, called
Discourse-tagged Multilingual Corpora, Chinatsu Aone, Scott W. Bennett   +2 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Discourse, of Course An overview of research in discourse studies

Discourse, of Course comes after Jan Renkema's Introduction to Discourse Studies (2004) for undergraduates. The new book is a collection of twenty short papers. It is a capita selecta course and meant for graduate programs.
Renkema, Jan.
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Curvilinear Relationship Between Confrontation Naming and Monologic Narrative Discourse in People With Aphasia: A Partial Replication With Expanded Analysis of Discourse. [PDF]

Am J Speech Lang Pathol
Carroll-Duhigg C, Dalton SG, Hsiao YY, Hubbard HI, Richardson JD.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Naming What Cannot Be Named: Discourse, Power, and the Erosion of Equity Language in Professional Nursing Standards-A Case Study of AACN's 2026 Essentials Revision. [PDF]

Nurs Inq
Ballout S, McKinley Yoder C.
europepmc   +1 more source