Results 111 to 120 of about 370,470 (313)

Discourse Analysis as Sociocriticism The Spanish Golden Age

open access: yes
Gómez-Moriana applies contemporary literary theory to classical texts of the Spanish Golden Age, including Lazirillo de Tormes, Don Quijote, Tirso de Molina's Don Juan play, and Columbus's Diary.Intro -- Contents -- Preface -- Introduction: Semiotics and
Gómez-Moriana, Antonio.
core  

Analysing children's accounts using discourse analysis

open access: yes, 2005
Discourse analytic approaches to research depart from understandings of the individual and of the relation between language and knowledge provided by positivist and post-positivist approaches.
Alldred, P, Burman, E
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Critical discourse analysis and the problem of methodology

open access: yes, 2009
The question of methodology in Critical Discourse Analysis (CDA) is complex and emergent as the field grows and develops after coming to prominence as a major arm of the broader field of discourse analysis over the past decade or so.
Otsuji, E, Lee, A
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mídia, cotidiano e cidade. Construções e desconstruções da observação como método

open access: yesMídia e Cotidiano, 2014
Utilizando a estética ensaística e a observação enquanto método de apropriação imediata do cotidiano, o texto pretende oferecer uma reflexão acerca das questões que envolvem o espaço, comunicação, mídia na sociedade atual.
paulo celso da silva
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

If on a winter’s night two researchers…: a challenge to assumptions of soundness of interpretation [PDF]

open access: yes, 2009
This paper reports on a quasi-experiment into triangulation, which is increasingly frequently cited as a guarantor of validity and reliability of findings.
Anna Marchi   +5 more
core  

The critical analysis of musical discourse

open access: yes, 2012
This paper argues that, contrary to what many musicologists and classical musicians have maintained, music can, and should, be analysed as discourse. It then surveys a number of approaches to the critical analysis of musical discourse and applies these ...
van Leeuwen, T
core   +1 more source

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