Results 201 to 210 of about 24,602,691 (327)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Ideas About the English Language in Early Technical Writing Textbooks

Discourse and Writing/Rédactologie, 1995
John Hagge
doaj   +1 more source

The inclusion of LGBTQ + people within UK health policy: a critical discourse analysis. [PDF]

Int J Equity Health
Braybrook D, Rosa WE, Norman C, Harding R, Bristowe K.   +4 more
europepmc   +1 more source

Critical Discourse Analysis as a Review Methodology: An Empirical Example

, 2015
Jeffrey D. Wall, Bernd Carsten Stahl, A. F. Salam   +2 more
openalex   +2 more sources

The Portrayal of the First Female Saudi Lawyer: A Multimodal Critical Discourse Analysis of Online Newspaper Articles

, 2020
Hessah S. Abaalalaa, Reem A. Alosaimi
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A discourse analysis of social inequities, gender, and stigma in tuberculosis policies of seven countries from Africa, Asia, Europe and South America. [PDF]

Glob Health Action
Valdivino M, de Vaulgrenant A, Horstman K, Chorna Y, Stein R, Chikovore J, Daftary A, Engel N.   +7 more
europepmc   +1 more source

Observation and Reflection of English Intensive Reading Classroom from the Perspective of Multimodal Discourse Analysis

, 2020
Zhe Guo
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Renewable energy for sustainable development in China: Discourse analysis. [PDF]

PLoS One
Jiang B, Raza MY.
europepmc   +1 more source