Results 231 to 240 of about 24,207,407 (408)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Correction: Media representations of China's inclusive education: A corpus-assisted critical discourse analysis. [PDF]

PLoS One
Yu Y, Lu G, Sin KF, Yu Z.
europepmc   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Representations of 'risky' drinking during pregnancy on Mumsnet: A discourse analysis. [PDF]

Drug Alcohol Rev
Schölin L, Arkell R.
europepmc   +1 more source

Role-theoretic discourse analysis of German security policy: a case of German parliamentary debate on the mission in Afghanistan. [PDF]

Front Psychol, 2023
Ni X.
europepmc   +1 more source

Narrative Structure and Characters in the Nanzi Stories of Curacao: a Discourse Analysis.

, 2000
Joke Mondada
openalex   +2 more sources

Off the Beaten Track: a Postmodern Feminist Analysis of Rural Midwifery and Rural Media Health Discourses [PDF]

, 2002
Jean Patterson
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Expectations, Tensions, and Brokerage: A Discourse Analysis of Community Engagement with Health Research in South Africa. [PDF]

Ethics Hum Res
Klingberg S, Draper CE.
europepmc   +1 more source

War on paper: A critical discourse analysis of war reporting in Ethiopia. [PDF]

Heliyon, 2023
Nigatu BA.
europepmc   +1 more source