Results 51 to 60 of about 24,602,691 (327)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
A corpus analysis of discourse relations for Natural Language Generation [PDF]
, 2003 We are developing a Natural Language Generation (NLG) system that generates texts tailored for the reading ability of individual readers. As part of building the system, GIRL (Generator for Individual Reading Levels), we carried out an analysis of the ...
Reiter, Ehud, Williams, Sandra
core +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
The Many Functions of Discourse Particles: A Computational Model of Pragmatic Interpretation [PDF]
, 1997 We present a connectionist model for the interpretation of discourse\ud particles in real dialogues that is based on neuronal\ud principles of categorization (categorical perception, prototype\ud formation, contextual interpretation).
Fischer, Kerstin, Scheler, Gabriele
core +2 more sources
Naukovì zapiski Nacìonalʹnogo unìversitetu «Ostrozʹka akademìâ». Serìâ «Fìlologìâ», 2020 The article examines and analyzes the linguistic and psychological features of political discourse using a computer-based Linguistic Inquiry and Word Count (LIWC) content analysis program to explore the relationship between political discourse and the ...
A. Yanovets, O. Smal
semanticscholar +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Introducing critical policy discourse analysis
Critical Policy Discourse Analysis, 2019 This volume presents ten empirical case studies that demonstrate the added value of integrating Critical Discourse Analysis (CDA) with Critical Policy Studies (CPS), producing a theoretical and methodological synergy we term Critical Policy Discourse ...
J. Mulderrig, N. Montessori, M. Farrelly
semanticscholar +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Intonation and discourse : biased questions [PDF]
, 2008 This paper surveys a range of constructions in which prosody affects discourse function and discourse structure.We discuss English tag questions, negative polar questions, and what we call “focus” questions.
Asher, Nicholas, Reese, Brian
core
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source