Results 231 to 240 of about 1,858,196 (253)

Author stance and engagement in research articles on educational equity: A comparison between Chinese and Australian authors. [PDF]

PLoS One
Li C, Wei R.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

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Are discourse markers related to age and educational background? A comparative account between two sign languages

Journal of Pragmatics, 2020
Sílvia Gabarró-López
exaly  

Using discourse segmentation to account for the polyfunctionality of discourse markers: The case of

Journal of Pragmatics, 2021
Salvador Pons Bordería, Kerstin Fischer
exaly  

The combining of Discourse Markers – A beginning

Journal of Pragmatics, 2015
Bruce Fraser
exaly  

Subjectivity, intersubjectivity and the historical construction of interlocutor stance: from stance markers to discourse markers

Discourse Studies, 2004
Susan Fitzmaurice
exaly  

Co-occurrence of discourse markers in English: From juxtaposition to composition

Journal of Pragmatics, 2019
Ludivine Crible, Maria Josep Cuenca
exaly  

Combinations of discourse markers with repairs and repetitions in English, French and Spanish

Journal of Pragmatics, 2020
Ludivine Crible
exaly