Results 81 to 90 of about 539,432 (273)
Rethinking network governance: new forms of analysis and the implications for IGR/MLG [PDF]
, 2010 Our position is that network governance can be understood as a communicative arena. Networks, then, are not defined by frequency of interactions between actors but by sharing of and contest between different clusters of ideas, theories and normative ...
farrelly, michael +2 more
core
When Are Tree Structures Necessary for Deep Learning of Representations? [PDF]
, 2015 Recursive neural models, which use syntactic parse trees to recursively generate representations bottom-up, are a popular architecture. But there have not been rigorous evaluations showing for exactly which tasks this syntax-based method is appropriate ...
Hovy, Eudard +3 more
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
, 2017 While recent neural encoder-decoder models have shown great promise in modeling open-domain conversations, they often generate dull and generic responses.
Eskenazi, Maxine +2 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Gender Ideology: an analysis methodology
Educação & Realidade, 2019 This paper proposes a two-step model for the inference of discourse on textual databases. The focus is on gender ideology and the action of EscolasemPartido.org and the Free Brazil Movement (Movimento Brasil Livre) on social networks, as well as the ...
Jasmine Moreira +1 more
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Abortion Ban in English Social Media in 2022: Pragmatic Linguistics of Online Communications
Виртуальная коммуникация и социальные сети, 2022 The present research featured the conflict discourse of online communication in social networks on the topic of abortion ban. The empirical base included 3,000,000 Twitter messages in English.
Anna A. Gnedash, Veronika V. Katermina
doaj +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source