Results 71 to 80 of about 1,070,023 (246)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Linking prominence, and other cues, to the processing of focus across languages

Laboratory Phonology
A key function of focus is to highlight what is said in relation to what could be said, or alternatives to the focus. This plays a crucial role in conveying implied meaning in discourse.
Sasha Calhoun
doaj   +2 more sources

Variation in the use and interpretation of null subjects: A view from Greek and Italian

Glossa, 2020
We aim to understand whether Greek and Italian, two null subject languages, differ in the use and interpretation of null subjects, based on evidence from both a production and a comprehension experiment.
Christiane M. Bongartz, Jacopo Torregrossa, Maria Andreou   +2 more
doaj   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Two Sides of the Same Coin? Investigating Iambic and Trochaic Timing and Prominence in German Poetry. [PDF]

, 2010
Wagner P. Two Sides of the Same Coin? Investigating Iambic and Trochaic Timing and Prominence in German Poetry. In: Proceedings of Speech Prosody 2010. 2010: P1.47.This paper examines the acoustic and perceptual properties of iambic vs.
Wagner, Petra ; https://orcid.org/
core  

A Textual Study of Turkish Overt and Null Singular Personal Pronouns in Novels

Discours
This study examines how Turkish overt and null singular subject pronouns are used in fiction novels. These pronouns are analysed focusing on their antecedents using the framework of Mira Ariel’s Accessibility Theory.
Buse Şen Erdoğan, Emine Yarar
doaj   +1 more source

Semantic relations cause interference in spoken language comprehension when using repeated definite references, not pronouns

Frontiers in Psychology, 2016
The choice and processing of referential expressions depend on the referents’ status within the discourse, such that pronouns are generally preferred over full repetitive references when the referent is salient.
Sara ePeters, Sara ePeters, Timothy W. Boiteau, Amit eAlmor   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Punctuation, prosody and discourse: afterthought vs. right dislocation

Frontiers in Psychology, 2015
In a reading production experiment, we investigate the impact of punctuation and discourse structure on the prosodic differentiation of right dislocation and afterthought. Both discourse structure and punctuation are likely to affect the prosodic marking
Janina eKalbertodt, Janina eKalbertodt, Beatrice ePrimus, Petra B. Schumacher   +3 more
doaj   +1 more source