Results 51 to 60 of about 284,503 (316)

10102 Executive Summary – Grand Challenges for Discrete Event Logistics Systems [PDF]

open access: yes, 2010
In March 2010, the Dagstuhl Seminar 10102 explored the grand challenges confronting research and practice in the domain of discrete event logistics systems.
McGinnis, Leon F.   +3 more
core   +1 more source

Good Systems Network Meeting [PDF]

open access: yes, 2020
You're viewing a past event from the Good Systems Grand Challenge team at The University of Texas at Austin that contains two presentations from May 19, 2020.Office of the VP for ...
Good Systems
core   +1 more source

Reformulation for the Diagnosis of Discrete-Event Systems

open access: yesAnnual Conference of the PHM Society, 2010
Diagnosis is traditionally defined on a space of hypotheses (typically, all the combinations of zero or more possible faults).In the present paper, we argue that a suitable reformulation of this hypothesis space can lead to more efficient diagnostic algorithms and more compact diagnoses, most notably by exploiting opportunities for various forms ...
Grastien A., Torta G.
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Modular nonblocking verification using conflict equivalence

open access: yes, 2006
This paper proposes a modular approach to verifying whether a large discrete event system is nonconflicting. The new approach avoids computing the synchronous product of a large set of finite-state machines.
Malik, Robi, Flordal, Hugo, Malik, Malik
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Rapid modeling of field maintenance using discrete event simulation [PDF]

open access: yes, 2011
Discrete event simulation has been applied to a wide range of applications areas due to its ability to represent stochastic systems over time. Maintenance, particularly field maintenance, is complex due to the interaction of different sub-systems of ...
Tiwari, Ashutosh   +5 more
core   +1 more source

Discrete Event Modeling and Simulation for Reinforcement Learning System Design

open access: yesInformation, 2022
Discrete event modeling and simulation and reinforcement learning are two frameworks suited for cyberphysical system design, which, when combined, can give powerful tools for system optimization or decision making process for example.
Laurent Capocchi   +1 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Verification of the observer property in discrete event systems

open access: yes, 2014
The observer property is an important condition to be satisfied by abstractions of Discrete Event System (DES) models. This technical note presents a new algorithm that tests if an abstraction of a DES obtained through natural projection has the observer
Pena, Patricia N.   +5 more
core   +1 more source

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