Results 21 to 30 of about 5,437 (226)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Discrete-Time Approximation of Stochastic Optimal Control with Partial Observation

SIAM Journal on Control and Optimization
23 ...
Yunzhang Li, Xiaolu Tan, Shanjian Tang
openaire   +3 more sources

A Discrete Dynamic Programming Approximation to the Multiobjective Deterministic Finite Horizon Optimal Control Problem [PDF]

SIAM Journal on Control and Optimization, 2009
Summary: This paper addresses the problem of finding an approximation to the minimal element set of the objective space for the class of multiobjective deterministic finite horizon optimal control problems. The objective space is assumed to be partially ordered by a pointed convex cone containing the origin.
A. Guigue, Mojtaba Ahmadi, M. J. D. Hayes, Robert G. Langlois   +3 more
openaire   +2 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Discrete approximate optimal vibration control for nonlinear vehicle active suspension [PDF]

Journal of Vibroengineering, 2017
This paper presents the approximate optimal vibration control methodology for discrete nonlinear vehicle active suspension subject to persistent road disturbances. Based on a dynamic model of nonlinear vehicle active suspension and a linear exogenous system model of the persistent road disturbances, a nonlinear two-point boundary value (TPBV) problem ...
Shi-Yuan Han, Xiao-Fang Zhong, Yue-Hui Chen, Gong-You Tang   +3 more
openaire   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Optimal control of a perturbed sweeping process via discrete discrete approximations

, 2015
26 ...
Cao, Tan H., Mordukhovich, Boris S.
openaire   +2 more sources

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

SUCCESSIVE APPROXIMATION METHOD BASED ON LOCAL APPROXIMATION OF THE REACHABLE SET FOR DISCRETE OPTIMAL CONTROL PROBLEMS

Izvestiya of Samara Scientific Center of the Russian Academy of Sciences, 2023
An improvement algorithm based on local approximations of the reachable set of a time-discrete optimal control problem is considered. Conditions are obtained that ensure the relaxation of the algorithm and the connection with the necessary optimality conditions.
V.A. Baturin, A.V. Daneev, V.N. Sizykh
openaire   +1 more source

Adaptive Observer for Coupled Wave PDE and Infinite ODE With Sampled Data and Unknown Input: Application to Brain Hemodynamics Estimation

International Journal of Adaptive Control and Signal Processing, EarlyView.
This article proposes a convergent adaptive observer for a damped wave PDE and an infinite‐dimensional ODE coupled in cascade using sampled‐in‐space ODE state measurements. The proposed observer estimates the distributed states of the PDE and ODE along with unknown PDE parameters and spatial input.
Zehor Belkhatir, Sarah Mechhoud, Taous‐Meriem Laleg‐Kirati   +2 more
wiley   +1 more source