Results 41 to 50 of about 80,420 (298)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Valuing SF-6Dv2 Using a Discrete Choice Experiment in a General Population in Quebec, Canada [PDF]

International Journal of Health Policy and Management
Background  An updated version of the Short-Form 6-Dimension (SF-6D) Classification System has been developed. This new version (SF-6Dv2) with improved consistency and dimension descriptors is now requiring the development of new utility value sets.
Hosein Ameri, Thomas G. Poder
doaj   +1 more source

A discrete choice experiment to explore carer preferences [PDF]

Quality in Ageing and Older Adults, 2017
Purpose The purpose of this paper is to describe a case study to test the applicability of the discrete choice experiment (DCE) method to assess the preferences of carers of people with dementia. The focus of enquiry was home care provision. Design/methodology/approach A multi-method approach was adopted for this pilot study.
Chester, Helen, Clarkson, Paul; id_orcid 0000-0002-0778-312X, Davies, Linda, Sutcliffe, Caroline, Roe, Brenda, Hughes, Jane, Challis, David   +6 more
openaire   +2 more sources

Using discrete choice modellinng to investigate breast screening participation

, 2008
The aim of this chapter is to show how discrete choice experiments (DCEs) can be applied to examine the preferences of women reinvited for breast screening and to use the results in developing breast screening participation enhancement ...
Gerard, Karen, Marian Shanahan, Jordan Louviere, Shanahan, Marian, Karen Gerard, Louviere, JJ, Louviere, Jordan, Gerard, K, Shanahan, M   +8 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Measurement and Modeling of Sustainable Food Choice and Purchasing Behavior: A Systematic Review of Methods and Models

Foods
Despite decades of methodological sophistication, research on sustainable food behavior remains critically limited in predicting actual purchases.
Tiago Negrão Andrade, Helena Maria André Bolini   +1 more
doaj   +1 more source

Trading Bankruptcy for Health: A Discrete-Choice Experiment [PDF]

Value in Health, 2018
Although nearly two-third of bankruptcy in the United States is medical in origin, a common assumption is that individuals facing a potentially lethal disease opt for cure at any cost. This assumption has never been tested, and knowledge of how the American population values a trade-off between cure and bankruptcy is unknown.To determine the relative ...
Shrime, M. G, Weinstein, M. C., Hammitt, James K., Cohen, Jessica, Salomon, Joshua   +4 more
openaire   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Willingness to Pay for Pesticides' Environmental Features and Social Desirability Bias: The Case of Apple and Pear Growers

Journal of Agricultural and Resource Economics, 2013
We conducted a discrete-choice experiment using direct and indirect valuation to determine the value apple and pear growers place on environmental features when choosing pesticides to control for first-generation codling moth.
R. Karina Gallardo, Qianqian Wang
doaj   +1 more source

Specification of the Utility Function in Discrete Choice Experiments [PDF]

Value in Health, 2014
The specification of the utility function has received limited attention within the discrete choice experiment (DCE) literature. This lack of investigation is surprising given that evidence from the contingent valuation literature suggests that welfare estimates are sensitive to different specifications of the utility function.This study investigates ...
van der Pol, Marjon, Currie, Gillian, Kromm, Seija, Ryan, Mandy   +3 more
openaire   +2 more sources