Results 41 to 50 of about 155,883 (264)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Performance Evaluation of Discrete Event Systems with GPenSIM
Computers, 2018 Petri nets are a useful tool for the modeling and performance evaluation of discrete event systems. Literature reveals that the Petri Net models of real-world discrete event systems are most frequently event graphs (a subclass of Petri nets).
Reggie Davidrajuh +2 more
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
A Numerical Study of Quantization-Based Integrators
ITM Web of Conferences, 2014 Adaptive step size solvers are nowadays considered fundamental to achieve efficient ODE integration. While, traditionally, ODE solvers have been designed based on discrete time machines, new approaches based on discrete event systems have been proposed ...
Barros Fernando
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i-Perception, 2020 In this Methods article, we discuss and illustrate a unifying, principled way to analyze response time data from psychological experiments—and all other types of time-to-event data.
Sven Panis +3 more
doaj +1 more source
Distributed discrete-event simulation [PDF]
ACM Computing Surveys, 1986 Traditional discrete-event simulations employ an inherently sequential algorithm. In practice, simulations of large systems are limited by this sequentiality, because only a modest number of events can be simulated. Distributed discrete-event simulation (carried out on a network of processors with asynchronous message-communicating capabilities) is ...
openaire +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Marked event method in discrete event simulation [PDF]
Proceedings of the 21st conference on Winter simulation - WSC '89, 1989 In this paper, we develop a new method for sensitivity analysis of discrete event dynamic systems. The method is based on the observation that event lists under nominal system parameters can be shared by simulations with slightly perturbed parameters. Thus the simulation on different system configurations may be more efficient.
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Stability of event synchronisation in distributed discrete event simulation [PDF]
Proceedings of the eighth workshop on Parallel and distributed simulation, 1994 This paper is concerned with the behaviour of message queues in distributed discrete event simula tors . We view a logical process in a distributed simulation as comprising a message sequencer with associated message queues, followed by an event processor.
Anurag Kumar 0001, Rajeev Shorey
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