Results 41 to 50 of about 2,967 (218)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Discrete Event System Specification for IoT Applications
SensorsThe Internet of Things (IoT) has emerged as a transformative technology with a variety of applications across various industries. However, the development of IoT systems is hindered by challenges such as interoperability, system complexity, and the need ...
Iman Alavi Fazel, Gabriel Wainer
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A Numerical Study of Quantization-Based Integrators
ITM Web of Conferences, 2014 Adaptive step size solvers are nowadays considered fundamental to achieve efficient ODE integration. While, traditionally, ODE solvers have been designed based on discrete time machines, new approaches based on discrete event systems have been proposed ...
Barros Fernando
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Performance Evaluation of Discrete Event Systems with GPenSIM
Computers, 2018 Petri nets are a useful tool for the modeling and performance evaluation of discrete event systems. Literature reveals that the Petri Net models of real-world discrete event systems are most frequently event graphs (a subclass of Petri nets).
Reggie Davidrajuh +2 more
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i-Perception, 2020 In this Methods article, we discuss and illustrate a unifying, principled way to analyze response time data from psychological experiments—and all other types of time-to-event data.
Sven Panis +3 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Stability of event synchronisation in distributed discrete event simulation [PDF]
Proceedings of the eighth workshop on Parallel and distributed simulation, 1994 This paper is concerned with the behaviour of message queues in distributed discrete event simula tors . We view a logical process in a distributed simulation as comprising a message sequencer with associated message queues, followed by an event processor.
Anurag Kumar 0001, Rajeev Shorey
openaire +2 more sources
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Event-Triggered Disturbance Rejection Control of Discrete Systems
IEEE Access, 2020 This paper considers event-triggered disturbance rejection control for discrete time linear systems. A novel event-based disturbance rejection controller is designed, and sufficient conditions are given to guarantee that the closed-loop system is ...
Peng Cheng +4 more
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