Results 111 to 120 of about 318,704 (275)

Cryo‐EM Structures Reveal the Molecular Basis of Asymmetric Allosteric Activation by MMOB in the Hydroxylase of Soluble Methane Monooxygenase

open access: yesAdvanced Science, EarlyView.
Cryo‐EM analysis reveals an asymmetric MMOH–MMOB complex with distinct protomers, where MMOB binding triggers structural rearrangements from the surface to the active site. This conformational asymmetry shortens the Fe···Fe distance to 2.7 Å in one protomer, forming a geometry suitable for O2 activation and supporting a sequential catalytic mechanism ...
Yunha Hwang   +9 more
wiley   +1 more source

A Novel Earth-System Spatial Grid Model: ISEA4H-ESSG for Multi-Layer Geoscience Data Integration and Analysis

open access: yesApplied Sciences
This paper presents a novel Earth-System Stratified Grid (ISEA4H-ESSG) model, designed to address the challenges in multi-layer geoscience data management and analysis.
Yue Ma   +3 more
doaj   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

open access: yesAdvanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong   +7 more
wiley   +1 more source

Spherical Gravity Forwarding of Global Discrete Grid Cells by Isoparametric Transformation

open access: yesMathematics
For regional or even global geophysical problems, the curvature of the geophysical model cannot be approximated as a plane, and its curvature must be considered.
Shujin Cao   +5 more
doaj   +1 more source

Accurate macroscale modelling of spatial dynamics in multiple dimensions

open access: yes, 2012
Developments in dynamical systems theory provides new support for the macroscale modelling of pdes and other microscale systems such as Lattice Boltzmann, Monte Carlo or Molecular Dynamics simulators.
Bunder, J. E.   +2 more
core  

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

open access: yesAdvanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian   +7 more
wiley   +1 more source

Exploring grid sensitivity in an ice sheet model: A case study of the Amery Ice Shelf

open access: yesAdvances in Climate Change Research
The dynamics of the Antarctic ice sheet are key factors affecting global climate change. To project future sea level changes, ice sheet models are developed based on a discrete grid system, which profoundly impacts the accuracy of numerical simulations ...
Qian-Xi Wang   +5 more
doaj   +1 more source

Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI

open access: yesAdvanced Science, EarlyView.
ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia   +7 more
wiley   +1 more source

Learnable Diffusion Framework for Mouse V1 Neural Decoding

open access: yesAdvanced Science, EarlyView.
We introduce Sensorium‐Viz, a diffusion‐based framework for reconstructing high‐fidelity visual stimuli from mouse primary visual cortex activity. By integrating a novel spatial embedding module with a Diffusion Transformer (DiT) and a synthetic‐response augmentation strategy, our model outperforms state‐of‐the‐art fMRI‐based baselines, enabling robust
Kaiwen Deng   +2 more
wiley   +1 more source

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