Results 151 to 160 of about 19,990 (183)

The Clinical Pharmacogenetics Implementation Consortium's consensus-based framework for assigning allele function. [PDF]

Am J Hum Genet
Tibben BM, Gaedigk A, Gong L, Sangkuhl K, Whirl-Carrillo M, Relling MV, Donnelly RS, Klein TE, Caudle KE.   +8 more
europepmc   +1 more source

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

Advanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang, Jie Dai, Ting Zhao, Shengjun Zhao, Hongyu Wu, Jiaying Pan, Yupeng Hao, Ke Nie, Li Yu, Yumeng Zhu, Xiangyi Zhao, Kai Huang, Mengke Zhang, Yongyan Zhao, Yaping Jiang, Siyuan Wang, Yiling Pan, Yubing Chen, Yilai Lin, Wanghong Shi, Yayuan Deng, Jin Han, Jie Li, Xuan Long, Junbin Wang, Zhiyuan Zhang, Zegang Han, Zhanfeng Si, Lei Ju, Jun Li, Tianzhen Zhang, Ji Zhou, Xueying Guan   +32 more
wiley   +1 more source

Neural representation of action symbols in primate frontal cortex. [PDF]

Nature
Tian LY, Garzón Gupta K, Hanuska DJ, Rouse AG, Eldridge MAG, Schieber MH, Wang XJ, Tenenbaum JB, Freiwald WA.   +8 more
europepmc   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

A direction aware predictive offloading framework for energy conscious mobile augmented reality systems. [PDF]

Sci Rep
Jebamani SA, Sathianesan GW.
europepmc   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

A Scheduling Method for Maintenance Tasks of Damaged Equipment Based on Digital Twin and Robust Optimization. [PDF]

Sensors (Basel)
Jiang M, Jiang T, Guo L, Liu S.
europepmc   +1 more source

A high-resolution beach imagery dataset with COCO annotations for deep learning-based <i>Sargassum</i> monitoring in coastal environments. [PDF]

Data Brief
Arellano-Verdejo J, Lazcano-Hernandez HE, Trejo-Morales A, Romero MS.   +3 more
europepmc   +1 more source

Riverscape heterogeneity shapes population diversity for a migratory fish. [PDF]

Ecol Appl
Baldock JR, Rosenthal WC, Al-Chokhachy RK, Campbell MR, Wagner CE, Walters A.   +5 more
europepmc   +1 more source