Results 41 to 50 of about 279,428 (288)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Simulation in manufacturing and business: A review [PDF]

, 2010
Copyright @ 2009 Elsevier B.V.This paper reports the results of a review of simulation applications published within peer-reviewed literature between 1997 and 2006 to provide an up-to-date picture of the role of simulation techniques within manufacturing
Aisha Naseer, Akkermans, Albino, Amoako-Gympah, Anderson, Antoniol, Arer, Arunachalam, Ashayeri, Ashworth, Ayag, Baines, Barman, Barton, Barua, Blocher, Bocker, Boel, Bosarth, Butler, Byrne, Cachon, Chan, Chan, Chan, Chatha, Chen, Chen, Christodoulou, Clark, De Ruyter, De Souza, De Treville, Durieux, Fleisch, Ford, Forssen, Gambardella, Giannini, Graham, Greasley, Greenhalgh, Grunow, Haas, Hahn, Hobbs, Hoesli, Hoogeweegen, Hueter, Hunt, Jacobson, Jahangirian, Jain, Jan, Kadipasaoglu, Kehris, Kellner, Kleijnen, Koh, Kwan, Kyamakya, Lainema, Lampros K. Stergioulas, Larsen, Lee, Lee, Lee, Lin, Lin, Liu, Love, Lukas, Lyneis, Lyneis, Lyneis, MacDonald, Machuca, Manzini, Marquez, Martin, McArthur, Mehra, Melao, Mendes, Mjema, Mohsen Jahangirian, Musselman, Nagano, Nance, Nass, Nassar, Noy, Olson, Orady, Otero-Novas, Owens, Pannirselvam, Park, Pfahl, Pfeil, Polat, Porter, Powell, Rabelo, Rabelo, Ranky, Reiner, Rodrigues, Rosen, Roser, Saltzman, Sawhney, Schwaninger, Schwartz, Shabayek, Shafer, Shafer, Shang, Smeds, Smith, Son, Spedding, Spengler, Sterman, Swain, Swaminathan, Taylor, Terry Young, Terzi, Theoharakis, Tillal Eldabi, Tofukuji, Van Der Vorst, Van Der Zee, Van Landeghem, Venkateswaran, Wenzler, Weston, Wolstenholme, Yan, Yazici, Yim, Zenios, Zha, Zulch, Zulch, Zülch   +146 more
core   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Discrete Event Simulation Method as a Tool for Improvement of Manufacturing Systems

Computers, 2017
The problem of production flow in manufacturing systems is analyzed. The machines can be operated by workers or by robots, since breakdowns and human factors destabilize the production processes that robots are preferred to perform. The problem is how to
Adrian Kampa, Grzegorz Gołda, Iwona Paprocka   +2 more
doaj   +1 more source

Development status and typical application of selective laser melting technology applications in aerospace field

Journal of Aeronautical Materials, 2021
Additive manufacturing technology (AM) is a new type of manufacturing technology based on the discrete-stacking principle and processing component with computer model data. Selective laser melting (SLM) is an important technology in the field of additive
YANG Jiaoxi, WU Wenliang, WANG Changliang, LIU Chenguang, WANG Shuzhi, YANG Daijun, ZHOU Zheng, XU Hongchao   +7 more
doaj   +1 more source

A Supervisory Control Algorithm Based on Property-Directed Reachability

, 2017
We present an algorithm for synthesising a controller (supervisor) for a discrete event system (DES) based on the property-directed reachability (PDR) model checking algorithm.
A Cimatti, AR Bradley, K Hoder, MR Shoaei, Z Hassan   +4 more
core   +2 more sources

Enabling Digital Continuity in Virtual Manufacturing for Eco‐Efficiency Assessment of Lightweight Structures by Means of a Domain‐Specific Structural Mechanics Language: Requirements, Idea and Proof of Concept

Advanced Engineering Materials, EarlyView.
This article presents a solver‐agnostic domain‐specific language (DSL) for computational structural mechanics that strengthens interoperability in virtual product development. Using a hierarchical data model, the DSL enables seamless exchange between diverse simulation tools and numerical methods.
Martin Rädel, Andreas Schuster, Felix Schoenitz, Jean Lefèvre   +3 more
wiley   +1 more source

Building reduced petri net models of discrete manufacturing systems

Mathematical and Computer Modelling, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rivera-Rangel, I., Ramírez-Treviño, A., López-Mellado, E.   +2 more
openaire   +2 more sources