Results 41 to 50 of about 1,918,409 (282)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
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Counting Tree-like Multigraphs with a Given Number of Vertices and Multiple Edges
MathematicsThe enumeration of chemical graphs plays a crucial role in cheminformatics and bioinformatics, especially in the search for novel drug discovery. These graphs are usually tree-like multigraphs, or they consist of tree-like multigraphs attached to a ...
Muhammad Ilyas +2 more
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Boundedness of Multidimensional Dunkl-Hausdorff Operators
Journal of Function Spaces, 2020 In the present paper, we introduce the multidimensional Dunkl-Hausdorff operator ℋκ and we give simple sufficient conditions so that these operators be bounded on the weighted lebesgue spaces Lκpℝn and in the Hardy space Hκ1ℝn associated with the Dunkl ...
Radouan Daher, Faouaz Saadi
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Chemistry and discrete mathematics
Discrete Applied Mathematics, 1996 This note serves as a preface to a special volume on chemistry and discrete mathematics of which the author is guest editor. His focus is on the problems of determining the number and structure of isomers and devising a distinguishing yet succinct nomenclature for cataloging molecules.
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Application of Discrete Mathematics for Programming Discrete Mathematics Calculations
, 2023 In the discrete mathematics courses, topics, such as the calculation of the element in any position of a sequence of numbers generated by some recurrence relation, calculation of multiplicative inverses in algebraic ring structures modulo a number n, obtaining the complete list of combinations without repetition, for which you can take advantage of the
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Digital technology in mathematics education: Why it works (or doesn't) [PDF]
, 2012 The integration of digital technology confronts teachers, educators and researchers with many questions. What is the potential of ICT for learning and teaching, and which factors are decisive in making it work in the mathematics classroom? To investigate
Drijvers, Paul +3 more
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BMC GenomicsBackground Understanding cellular diversity throughout the body is essential for elucidating the complex functions of biological systems. Recently, large-scale single-cell omics datasets, known as omics atlases, have become available.
Daigo Okada +4 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source