Results 31 to 40 of about 131,030 (317)

Integrated optimization of timetabling and Electric Vehicle Scheduling

EURO Journal on Transportation and Logistics
We tackle the integrated planning problem of periodic timetabling and electric vehicle scheduling, crucial for cities transitioning to electric bus fleets.
Vladimir Stadnichuk, Jenny Segschneider, Arie M.C.A. Koster, Grit Walther   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Robust balanced optimization [PDF]

, 2018
An instance of a balanced optimization problem with vector costs consists of a ground set X, a cost-vector for every element of X, and a system of feasible subsets over X.
Spieksma, F.C.R., Ficker, Annette M. C., Ficker, Annette M.C., Spieksma, Frits C.R., Woeginger, Gerhard, Spieksma, FCR, Woeginger, GJ Gerhard, Spieksma, Frits C. R., AnnetteM.C. Ficker, Woeginger, G., Ficker, AMC Annette, Spieksma, F.C.R.; id_orcid, Ficker, A.M.C., Ficker, Annette, Spieksma, Frits, GerhardJ. Woeginger, Woeginger, Gerhard J., FritsC.R. Spieksma   +17 more
core   +1 more source

Convex Discrete Optimization [PDF]

, 2008
We develop an algorithmic theory of convex optimization over discrete sets. Using a combination of algebraic and geometric tools we are able to provide polynomial time algorithms for solving broad classes of convex combinatorial optimization problems and convex integer programming problems in variable dimension. We discuss some of the many applications
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Sparse Gaussian Processes on Discrete Domains

IEEE Access, 2021
Kernel methods on discrete domains have shown great promise for many challenging data types, for instance, biological sequence data and molecular structure data.
Vincent Fortuin, Gideon Dresdner, Heiko Strathmann, Gunnar Ratsch   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Generalised verification of the observer property in discrete event systems

, 2012
The observer property is an important condition to be satisfied by abstractions of Discrete Event Systems (DES) models. This paper presents a generalised version of a previous algorithm which tests if an abstraction of a DES obtained through natural ...
Pena, Patricia N., da Cunha, A. E. C., Malik, Robi, Cury, José E. R., Bravo, H. J.   +4 more
core   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source