Results 31 to 40 of about 1,259,252 (332)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Artificial Life in an Exciton-Polariton Lattice

, 2020
We show theoretically that a lattice of exciton-polaritons can behave as a life-like cellular automaton when simultaneously excited by a continuous wave coherent field and a time-periodic sequence of non-resonant pulses.
Banerjee, R., Liew, T. C. H.
core   +1 more source

MODELING OF VIBRATIONAL PROCESSES IN DISCRETE MATRIX STRUC-TURES APPROACH

Радіоелектронні і комп'ютерні системи, 2020
In the article are presented general principles of modeling vibrations in discrete structures formed in the form of special matrix forms of the Latin square (Sudoku type) are presented.
Yuriy Penkin, Georgi Hara, Alina Fedoseeva   +2 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Discrete Structure of the Brain Rhythms [PDF]

Scientific Reports, 2019
AbstractNeuronal activity in the brain generates synchronous oscillations of the Local Field Potential (LFP). The traditional analyses of the LFPs are based on decomposing the signal into simpler components, such as sinusoidal harmonics. However, a common drawback of such methods is that the decomposition primitives are usually presumed from the onset,
Perotti, L., DeVito, J., Bessis, D., Dabaghian, Y.   +3 more
openaire   +3 more sources

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Discrete Convex Functions on Graphs and Their Algorithmic Applications

, 2017
The present article is an exposition of a theory of discrete convex functions on certain graph structures, developed by the author in recent years.
A Bernáth, A Frank, AV Goldberg, AV Karzanov, AV Karzanov, AV Karzanov, AWJ Kolen, BC Tansel, E Anshelevich, F Kuivinen, G Grätzer, H Hirai, H Hirai, H Hirai, H Hirai, H-J Bandelt, J Kleinberg, K Murota, K Murota, K Murota, MA Babenko, MR Bridson, N Garg, P Abramenko, P Favati, R Hassin, S Fujishige, S Fujishige, S Fujishige, S Fujishige, S Fujishige, S Živný, T Fukunaga, V Chepoi, V Kolmogorov, VV Vazirani, Y Iwata   +36 more
core   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Creation of discrete solitons and observation of the Peierls-Nabarro barrier in Bose-Einstein Condensates

, 2003
We analyze the generation and mobility of discrete solitons in Bose-Einstein condensates confined in an optical lattice under realistic experimental conditions.
A. Sanpera, D. N. Christodoulides, L. Santos, M. H. Anderson, M. Lewenstein, P. Meystre, P. Pedri, V. Ahufinger, W. Zwerger, Y. S. Kivshar   +9 more
core   +1 more source

Development of a Personalized Visualization and Analysis Tool to Improve Clinical Care in Complex Multisystem Diseases With Application to Scleroderma

Arthritis Care &Research, EarlyView.
Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of the trajectory of a ...
Ji Soo Kim, John Scott, Lauren Fisher, Lauren N. Smith, Willie Stewart, Adrianne Woods, Rob Smithwright, Diane Koher, Parastoo Aslanbeik, Aalok B. Shah, Brad Tibbils, Samantha I. Pitts, Ayse P. Gurses, Yushi Yang, Ana‐Maria Orbai, Antony Rosen, Laura K. Hummers, Scott L. Zeger, Ami A. Shah   +18 more
wiley   +1 more source