Results 41 to 50 of about 1,485,910 (226)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A Unified Method for Detecting Phylogenetic Signals in Continuous, Discrete, and Multiple Trait Combinations

Ecology and Evolution
Phylogenetic signals are widely used in ecological and evolutionary studies. Trait data used to detect phylogenetic signals can be continuous or discrete, but existing indices are designed for either type, not both.
Liang Yao, Ye Yuan
doaj   +1 more source

Determining correlation between probability of stability and reliability at discrete systems [PDF]

Tehnika, 2015
The existence of correlation between probability of stability and reliability of discrete dynamical systems is proven in this paper. Calculated correlation coefficient shows very high level of correlation.
Zlatković Bojana M., Samardžić Biljana M.   +1 more
doaj   +1 more source

Discrete Hamilton-Jacobi Theory

, 2011
We develop a discrete analogue of Hamilton-Jacobi theory in the framework of discrete Hamiltonian mechanics. The resulting discrete Hamilton-Jacobi equation is discrete only in time.
Anthony M. Bloch, Elnatanov N. A., Melvin Leok, Tomoki Ohsawa   +3 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Numerical Solution for Classical Optimal Control Problem Governing by Hyperbolic Partial Differential Equation via Galerkin Finite Element-Implicit method with Gradient Projection Method

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2019
     This paper deals with the numerical solution of the discrete classical optimal control problem (DCOCP) governing by linear hyperbolic boundary value problem (LHBVP). The method which is used here consists of: the GFEIM " the Galerkin finite element
Jamil A. Ali Al-Hawasy, Eman H. Al-Rawdanee   +1 more
doaj   +1 more source

A note on negative λ-binomial distribution

Advances in Difference Equations, 2020
In this paper, we introduce one discrete random variable, namely the negative λ-binomial random variable. We deduce the expectation of the negative λ-binomial random variable.
Yuankui Ma, Taekyun Kim
doaj   +1 more source

The Effect of Caputo Fractional Variable Difference Operator on a Discrete-Time Hopfield Neural Network with Non-Commensurate Order

Fractal and Fractional, 2022
In this work, we recall some definitions on fractional calculus with discrete-time. Then, we introduce a discrete-time Hopfield neural network (D.T.H.N.N) with non-commensurate fractional variable-order (V.O) for three neurons.
Rabia Chaimaà Karoun, Adel Ouannas, Mohammed Al Horani, Giuseppe Grassi   +3 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A Modified Jaya Algorithm for Mixed-Variable Optimization Problems

Journal of Intelligent Systems, 2018
Mixed-variable optimization problems consist of the continuous, integer, and discrete variables generally used in various engineering optimization problems.
Singh Prem, Chaudhary Himanshu
doaj   +1 more source