Results 41 to 50 of about 175,712 (266)

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Beyond the Gaussian

Symmetry, Integrability and Geometry: Methods and Applications, 2011
In this paper we present a non-Gaussian integral based on a cubic polynomial, instead of a quadratic, and give a fundamental formula in terms of its discriminant. It gives a mathematical reinforcement to the recent result by Morozov and Shakirov. We also
Kazuyuki Fujii
doaj   +1 more source

Hierarchical Discriminant Analysis

Sensors, 2018
The Internet of Things (IoT) generates lots of high-dimensional sensor intelligent data. The processing of high-dimensional data (e.g., data visualization and data classification) is very difficult, so it requires excellent subspace learning algorithms ...
Di Lu, Chuntao Ding, Jinliang Xu, Shangguang Wang   +3 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Reversible Discriminant Analysis

IEEE Access, 2018
Principal component analysis (PCA) and linear discriminant analysis (LDA) have been extended to be a group of classical methods in dimensionality reduction for unsupervised and supervised learning, respectively.
Lan Bai, Zhen Wang, Yuan-Hai Shao, Chun-Na Li   +3 more
doaj   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

Some discriminants for the formability of thin-walled tubes of aluminum alloy in internal inversion process on fillet die

工程科学与技术, 2009
: Based on the relations among the stress, final wall-thickness of thin-walled tube and the characteristics of tube material, original size, curling radius along with friction condition in a axially-compressed internal inversion process on right-angled
Niu Wei-Zhong
doaj  

Gender Determination from Digital Lateral Cephalogram for an Adolescent and Adult Cohort from a Pondicherry Population – A Cross-Sectional Study

Journal of Indian Academy of Oral Medicine and Radiology
Background: Identifying sex from a skull is a test for a forensic odontologist. There are research done to determine sex based on cranial values.
Rajkumar Couppoussamy, M Jonathan Daniel, Srinivasan Subramanian Vasudevan, Jimsha Vanathan Kumaran   +3 more
doaj   +1 more source

Sugarcane yield forecast using weather based discriminant analysis

Smart Agricultural Technology, 2023
Discriminant function analysis has been used for forecasting of Sugarcane yield of Coimbatore district in Tamilnadu. Crop yield has been classified into two and three groups.
S R Krishan Priya, R Keerti Balambiga, Pradeep Mishra, Soumitra Sankar Das   +3 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source