Results 91 to 100 of about 569,150 (248)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Experiences of discrimination are associated with microbiome and transcriptome alterations in the gut

Frontiers in Microbiology
BackgroundDiscrimination is a recognized psychosocial stressor that has been linked to various negative health outcomes. This study explored the impact of discrimination on gut health, specifically focusing on microbiome changes, predicted metagenomic ...
Tien S. Dong, Tien S. Dong, Tien S. Dong, Tien S. Dong, Tien S. Dong, Simer Shera, Kirstin Peters, Gilbert C. Gee, Gilbert C. Gee, Hiram Beltrán-Sánchez, Hiram Beltrán-Sánchez, May C. Wang, Lisa A. Kilpatrick, Lisa A. Kilpatrick, Lisa A. Kilpatrick, Lisa A. Kilpatrick, Xiaobei Zhang, Xiaobei Zhang, Xiaobei Zhang, Xiaobei Zhang, Xiaobei Zhang, Jennifer S. Labus, Jennifer S. Labus, Jennifer S. Labus, Jennifer S. Labus, Jennifer S. Labus, Allison Vaughan, Allison Vaughan, Allison Vaughan, Allison Vaughan, Arpana Church, Arpana Church, Arpana Church, Arpana Church, Arpana Church   +34 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Discrimination Analysis of Conventional Baijiu-making Sorghum from Southwest China and Hybrid Sorghum Based on Physicochemical Properties and Metabolomics

Shipin gongye ke-ji
The objective of this paper was to analyze the difference of composition between hybrid sorghum and conventional sorghum in southwest China, and to establish the method of variety identification.
Hongmei WANG, Zhe LI, Songtao WANG, Qingliang ZHANG, Anjing CHEN, Ling LI, Rongkun TU   +6 more
doaj   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Introduction to the symposium on Race, Racism, and International Law

AJIL Unbound, 2023
E. Tendayi Achiume, James Thuo Gathii
doaj   +1 more source

Characterizing Asian American medical students’ experiences with microaggression and the impact on their well-being

Medical Education Online
Purpose This mixed-methods study quantified and characterized incidents of microaggressions experienced by Asian American medical students. The authors report on their impact and suggest improvements to create a more equitable and supportive learning ...
Lindy Zhang, Crystal An, Joanna Chen, B U.K. Li, Sunny Nakae, Joyce Pang   +5 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Explaining Discrimination

Experiments on ethnic or racial discrimination often use names to signal originin market situations under the assumption that non-ethnic name signals do notsystematically affect the outcome. Using survey data, we demonstrate significantvariation in perceived trustworthiness and professionalism of names within origins.Linking this to a large-scale name ...
Billie Martiniello, Daniel Auer, Didier Ruedin   +2 more
openaire   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source