Results 111 to 120 of about 1,158,568 (364)

The entropic discriminant

open access: yesAdvances in Mathematics, 2013
The entropic discriminant is a non-negative polynomial associated to a matrix. It arises in contexts ranging from statistics and linear programming to singularity theory and algebraic geometry. It describes the complex branch locus of the polar map of a real hyperplane arrangement, and it vanishes when the equations defining the analytic center of a ...
Raman Sanyal   +2 more
openaire   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

A survey on measuring indirect discrimination in machine learning [PDF]

open access: yesarXiv, 2015
Nowadays, many decisions are made using predictive models built on historical data.Predictive models may systematically discriminate groups of people even if the computing process is fair and well-intentioned. Discrimination-aware data mining studies how to make predictive models free from discrimination, when historical data, on which they are built ...
arxiv  

Implicit Discrimination

open access: yes, 2018
Implicit Discrimination Author(s): Marianne Bertrand, Dolly Chugh and Sendhil Mullainathan Source: The American Economic Review, Vol. 95, No. 2, Papers and Proceedings of the One Hundred Seventeenth Annual Meeting of the American Economic Association ...

semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Achieving non-discrimination in data release [PDF]

open access: yesarXiv, 2016
Discrimination discovery and prevention/removal are increasingly important tasks in data mining. Discrimination discovery aims to unveil discriminatory practices on the protected attribute (e.g., gender) by analyzing the dataset of historical decision records, and discrimination prevention aims to remove discrimination by modifying the biased data ...
arxiv  

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Race, Ethnicity and National Origin-based Discrimination in Social Media and Hate Crimes Across 100 U.S. Cities [PDF]

open access: yesarXiv, 2019
We study malicious online content via a specific type of hate speech: race, ethnicity and national-origin based discrimination in social media, alongside hate crimes motivated by those characteristics, in 100 cities across the United States. We develop a spatially-diverse training dataset and classification pipeline to delineate targeted and self ...
arxiv  

Discrimination in medicine

open access: yesBMJ, 2002
As the current political situation in France shows, discrimination is rife. So why should the situation in medicine be any different? The 50 rapid responses to our recent editorial on racism in medicine are proof that discrimination in medicine is alive and well.1 This is hardly surprising in a culture where a consultant surgeon thinks there is nothing
openaire   +4 more sources

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