Results 31 to 40 of about 176,051 (264)

Post-training depletions of basolateral amygdala serotonin fail to disrupt discrimination, retention, or reversal learning

Frontiers in Neuroscience, 2015
In goal-directed pursuits, the basolateral amygdala (BLA) is critical in learning about changes in the value of rewards. BLA-lesioned rats show enhanced reversal learning, a task employed to measure the flexibility of response to changes in reward ...
G. Jesus eOchoa, Alexandra eStolyarova, Amandeep eKaur, Evan eHart, Amador eBugarin, Alicia eIzquierdo   +5 more
doaj   +1 more source

Assessment of Replicability and Efforts to Refine an Operant Conditioning Procedure for Larval Zebrafish

Animals
The zebrafish model is rapidly advancing numerous areas of basic and translational research, including toxicology, drug discovery, molecular genetics, genomic research, developmental biology, and the study of human diseases (reviewed in [...]
Christian Agrillo, Eleonora Rovegno, Marco Dadda, Cristiano Bertolucci, Angelo Bisazza   +4 more
doaj   +1 more source

Rapid Discriminative Learning

Journal of Advanced Computational Intelligence and Intelligent Informatics, 2004
This paper presents MCE/GPD using GPD that is known as a highly effective discriminative learning method. MCE/GPD is an excellent recognition method that is applicable especially to speech recognition, since it excels in recognizing performance and can be used to deal with variable-length vectors.
openaire   +1 more source

Learning to discriminate face view

Journal of Vision, 2010
Although perceptual learning of simple visual features has been studied extensively and intensively for many years, we still know little about the mechanisms of perceptual learning of complex object recognition. In a series of seven experiments, human perceptual learning in discrimination of in-depth orientation of face view was studied using ...
Taiyong, Bi, Nihong, Chen, Qiujie, Weng, Dongjun, He, Fang, Fang   +4 more
openaire   +2 more sources

Learning complex texture discrimination

Journal of the Optical Society of America A, 2018
Higher-order spatial correlations contribute strongly to visual structure and salience, and are common in the natural environment. One method for studying this structure has been through the use of highly controlled texture patterns whose obvious structure is defined entirely by third- and higher-order correlations.
T. Maddess, D. Coy, J. C. Herrington, C. F. Carle, F. Sabeti, M. S. Barbosa   +5 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Learning to Write with Cooperative Discriminators [PDF]

Proceedings of the 56th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), 2018
Recurrent Neural Networks (RNNs) are powerful autoregressive sequence models, but when used to generate natural language their output tends to be overly generic, repetitive, and self-contradictory. We postulate that the objective function optimized by RNN language models, which amounts to the overall perplexity of a text, is not expressive enough to ...
Ari Holtzman, Jan Buys, Maxwell Forbes, Antoine Bosselut, David Golub, Yejin Choi 0001   +5 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source