Results 51 to 60 of about 1,103,360 (305)

Systemic Discrimination: Theory and Measurement

The Quarterly Journal of Economics, 2022
Abstract Economists often measure discrimination as disparities arising from the direct effects of group identity. We develop new tools to model and measure systemic discrimination, capturing how discrimination in other decisions indirectly contributes to disparities.
J. Aislinn Bohren, Peter Hull, Alex Imas
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Two-point orientation discrimination versus the traditional two-point test for tactile spatial acuity assessment

Frontiers in Human Neuroscience, 2013
Two-point discrimination is widely used to measure tactile spatial acuity. The validity of the two-point threshold as a spatial acuity measure rests on the assumption that two points can be distinguished from one only when the two points are sufficiently
Jonathan eTong, Oliver eMao, Daniel eGoldreich   +2 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Visual processing in reading disorders and attention-deficit/hyperactivity disorder and its contribution to basic reading ability

Frontiers in Psychology, 2015
Whether visual processing deficits are common in reading disorders (RD), and related to reading ability in general, has been debated for decades. The type of visual processing affected also is debated, although visual discrimination and short-term memory
Michelle Y. Kibby, Sarah M Dyer, Sarah A Vadnais, Audreyana C Jagger, Gabriel A Casher, Maria eStacy   +5 more
doaj   +1 more source

Discriminant Measures for Desperate Love

Journal of Personality Assessment, 1985
Viewing desperate love as marked by urgency, neediness, dependence, a great need for reciprocation, indealization, and affective extremes, personality traits leading to desperate love were examined. A sample of 251 undergraduates, in desperate love, nondesperate love, and random groups, completed several questionnaires examining characteristic ...
openaire   +4 more sources

Discriminating between alternative measures of over-education [PDF]

Applied Economics, 2006
Five over-education measures are evaluated empirically on the basis of encompassing tests. The measures are based on job analysis (JA), worker-assessment of the required level to do the job (WAd), worker-assessment of the required level to get the job (WAg), the mean educational level of realized matches (RMmn), and the modal level of realized matches (
Verhaest, Dieter, Omey, Eddy
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Who feels safe calling 911: are prior experiences of anti-Black racial discrimination associated with hesitancy seeking emergency medical services in the event of accidental drug overdose? – a study protocol

Annals of Medicine
Background Racial discrimination is associated with health disparities among Black Americans, a group that has experienced an increase in rates of fatal drug overdose.
O. Trent Hall, Candice Trimble, Stephanie Garcia, Sydney Grayson, Lucy Joseph, Parker Entrup, Oluwole Jegede, Jose Perez Martel, Jeanette Tetrault, Myra Mathis, Ayana Jordan   +10 more
doaj   +1 more source