Results 51 to 60 of about 40,865 (297)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Reliable and Faithful Generative Explainers for Graph Neural Networks
Machine Learning and Knowledge ExtractionGraph neural networks (GNNs) have been effectively implemented in a variety of real-world applications, although their underlying work mechanisms remain a mystery.
Yiqiao Li +4 more
doaj +1 more source
Pareto Optimized Large Mask Approach for Efficient and Background Humanoid Shape Removal
IEEE Access, 2023 The purpose of automated video object removal is to not only detect and remove the object of interest automatically, but also to utilize background context to inpaint the foreground area.
Rytis Maskeliunas +3 more
doaj +1 more source
No Modes left behind: Capturing the data distribution effectively using GANs
, 2018 Generative adversarial networks (GANs) while being very versatile in realistic image synthesis, still are sensitive to the input distribution. Given a set of data that has an imbalance in the distribution, the networks are susceptible to missing modes ...
Namboodiri, Vinay P., Sharma, Shashank
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Supervised Machine Learning Algorithms to Discriminate Two Similar Marble Varieties, a Case Study [PDF]
, 2023 Lluı̀s Casas +4 more
openalex +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source