Leger est aprendre mes fort est arendre;: Wool, Debt and the Dispersal of Pipewell Abbey (1280 - 1330) [PDF]
has long been known that English Cistercian monasteries often sold their wool in advance to foreign merchants in the late thirteenth century. The abbey of Pipewell in Northamptonshire features in a number of such contracts with Cahorsin merchants.
Adrian Bell, Chris Brooks, Paul Dryburgh
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Comment on: CATALYZE: a deep learning approach for cataract assessment and grading on SS-OCT images. [PDF]
J Cataract Refract SurgNi J.
europepmc +1 more source
Illicit drugs and cluster headache: An inevitable discussion [PDF]
, 2012 Arne May
openalex +1 more source
Stocks, Bond and Hedge Funds: Not a Free Lunch [PDF]
We study the diversification effects from introducing hedge funds into a traditional portfolio of stocks and bonds. Our results make it clear that in terms of skewness and kurtosis equity and hedge funds do not combine very well.
Gaurav Amin, Harry. M Kat
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
"Best-advice" and the "true" mortgate term. Actuaries' endowment advice principles revisited [PDF]
In 1999 the Financial Services Authority recommended that a standard repayment mortgage was the “best advice” for Independent Financial Advisors to give to essentially all new mortgage customers seeking the best value repayment vehicle.
Andrew Godley
core
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Editorial: A year in review: discussions in adrenal endocrinology
Frontiers in Endocrinology, 2023 Ivana Kraljevic, Ivana Kraljevic
doaj +1 more source
Clinical Clu-Dr: A Scalable Gamified Tool for Clinical Reasoning Practice. [PDF]
Clin TeachHorniblow RD +7 more
europepmc +1 more source