Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Manner and Functions of Discussion in the Prophet’s Conduct An Analysis based on the Theory of Communicative Action [PDF]
اسلام و مطالعات اجتماعی, 2014 Discussion, which is an unavoidable necessity for establishing agreement and eliminating disputesand growingthought in human life, has been the subject of study for different philosophicalschools and intellectual trends.
Mohsen Alviri, Hossein Mehrbanifar
doaj
Viewpoint: Toward a new generation of land use transport interaction models
Journal of Transport and Land Use, 2015 Land use transport interaction (LUTI) models are often developed to model the interaction between the land use and trans- port systems for relatively large-scale spatial developments, like new residential or office areas, new main roads, or railway lines.
Bert van Wee
doaj +1 more source
Economic and social impact of introducing casino gambling: a review and assessment of the literature [PDF]
Reviews and assesses the existing literature on the potential economic impact of introducing casino gambling into a community or region, first by discussing the casinos?
Alan Mallach
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Breast cancer prevention behaviour of nurses and midwives - introduction to the discussion
Journal of Education, Health and SportIntroduction Nurses and midwives are a large and therefore very important - for the population effect of many public health activities - group of health care professionals. Breast cancer prevention is one of them.
Marianna Charzyńska-Gula +5 more
doaj +1 more source
HUMANISTIC FOUNDATIONS OF FOREIGN LANGUAGE EDUCATION: THEORY AND PRACTICE
Novìtnâ Osvìta, 2018 The paper focuses on the theoretical analysis of psychological and pedagogic foundations of humanistic foreign language education viewed as an interrelated subject-subject system for improving the emotional and intellectual spheres of students’ personal
Svitlana Fedorenko
doaj +1 more source
Detecting Switching Strategies in Equity Hedge Funds [PDF]
Equity hedge funds are thought to effectively operate market timing by implementing switching strategies conditional on market circumstances. In this paper we use only the reported monthly returns on a set of funds to infer the type of switching ...
Anca Dimitriu, Carol Alexander
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source