Results 91 to 100 of about 4,880,932 (242)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Factors Affecting Students’ Participation in Classroom Discussions [PDF]
Journal of Islamic Studies, 1990 This study was designed to survey students‘ opinions concerning their lack of active participation in classroom discussions. A random sample of 608 students was used from the School of Education; in Abha and their responses to a 30 item questionnaire ...
Ali M. Al-Massawry +1 more
doaj
Manifestation of tolerance / intolerance in non-professional discussions of media users (based on linguistic discussions) [PDF]
Известия Саратовского университета. Новая серия: Серия Филология, ЖурналистикаPublications of users in various non-institutional media on current and controversial topics of a professional nature, as well as comments to them by other "amateur" users, are in the zone of tolerant tension due to a number of reasons ...
Antropova, Vera Владимировна
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
DISCUSSIONS REGARDING THE PRESCRIPTION IN CRIMINAL LAW [PDF]
This study displays certain controversial issues related to the prescription of criminal liability and the prescription of the punishment execution, analyzing them both theoretically and practically, based on the resolutions of the courts in Romania ...
Ramona Mihaela MOLDOVAN
core
Addressing Religion and Spirituality in Psychotherapy: Clients\u27 Perspectives [PDF]
, 2005 Twelve adult clients described the role of religion and spirituality in their lives and in therapy as a whole, as well as their specific experiences of discussing religious-spiritual topics in individual outpatient psychotherapy with nonreligiously ...
Casper, Margaret +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source