Results 121 to 130 of about 10,714,680 (266)

Disease-free survival analysis of HPV+ patients (N = 49) compared to HPV- patients (log-rank p< 0.001).

, 2018
Disease-free survival analysis of HPV+ patients (N = 49) compared to HPV- patients (log-rank p< 0.001).
Herikson Araújo Costa (5851490), Gyl Eanes Barros Silva (5100281), Antonio Augusto Lima Teixeira Júnior (5851475), José de Ribamar Rodrigues Calixto (5851487), Leudivan Ribeiro Nogueira (5851478), Fábio França Silva (5851481), André Salim Khayat (394567), Victor Eduardo Maulen (5851484), Jaqueline Diniz Pinho (5851472), Leandra Naira Zambelli Ramalho (162689), Vicenilma de Andrade Martins (5851469)   +10 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis

Frontiers in Oncology
BackgroundIncreased PD-1 expression on CD8+ T cells is considered as a hallmark for T-cell exhaustion, and is thought to be related to the prognosis of cancer patients.
Zhiyong Wan, Meng Cui, Jia Yang, Dan Liao, Junliang Chen, Fanmin Li, Yin Xiang, Zhiwei Cui, Yang Yang   +8 more
doaj   +1 more source

Impact of adjuvant radiotherapy on locoregional recurrence-free survival (A) and disease-free survival (B) in high-risk patients.

, 2015
Impact of adjuvant radiotherapy on locoregional recurrence-free survival (A) and disease-free survival (B) in high-risk patients.
Juan Zhou (207536), Jia-Yuan Sun (406033), Zhen-Yu He (406032), Qin Lin (406035), San-Gang Wu (406031), Fang-Yan Li (703933), Huan-Xin Lin (131044)   +6 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Kaplan-Meier curves for disease-free survival.

, 2014
TGF-β, HIF-1α, VEGF and pERK 1/2 overexpression were divided into an overexpression group and a weak-expression group. A log-rank test was used to calculate significance. A. Disease-free survival curves stratified by TGF-β expression (P = 0.053).
Li Chen (5749), Baoqing Jia (533203), Guanghai Dai (533204), Jing Yuan (217967), Lixin Wei (83825), Qian Wu (209382), Shunchang Jiao (533205), Rui Qin (533202), Yan Shi (166398), Bo Wei (188204), Yalin Han (533201)   +10 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Overall Survival and Disease-Free Survival in patients with early relapse according to residual disease status (Kaplan Meier analysis).

, 2016
Overall Survival and Disease-Free Survival in patients with early relapse according to residual disease status (Kaplan Meier analysis).
Paul Guerby (2183926), Eric Leblanc (314676), Philippe Morice (314664), Christophe Pomel (2183920), Jean Marc Classe (2183923), Fabrice Lecuru (314671), Denis Querleu (192101), Thomas Filleron (2183932), Arash Rafii (102768), Pascale Haddad (678636), Eberhard Stoeckle (154353), Gwenael Ferron (314660), Fabien Vidal (474030), Mathieu Luyckx (2183917), Emile Daraï (2183929)   +14 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source