Results 51 to 60 of about 10,714,680 (266)
Cancer Cell International, 2019 Background Enhanced glycolysis in tumors, known as the Warburg effect, provides the metabolic basis of enhanced cancer cell proliferation and metastasis.
Ling Yao +4 more
doaj +1 more source
Disease-free survival (DFS) according to OHE status (spayed vs intact), log rank p = 0.026.
, 2019 Disease-free survival (DFS) according to OHE status (spayed vs intact), log rank p = 0.026.
Veronica Kristiansen (4229782) +6 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The relationship between diabetes and colorectal cancer prognosis: A meta-analysis based on the cohort studies. [PDF]
PLoS ONE, 2017 Though a meta-analysis reported the effect of diabetes on colorectal prognosis in 2013, a series of large-scale long-term cohort studies has comprehensively reported the outcome effect estimates on the relationship between diabetes and colorectal ...
Bo Zhu +5 more
doaj +1 more source
Comparison of disease-free-survival and overall survival with respect to TP53 mutation.
, 2014 Disease-free-survival and overall survival are not different between TP53 mutation-negative group and TP53 mutation-positive group. A and B, Disease-free-survival and overall survival in total EOC patients (n = 46, 36 TP53 mutation (−) vs.
Dae-Yeon Kim (579234) +11 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Frontiers in OncologyBackgroundCirculating tumor DNA (ctDNA) is an emerging biomarker in cervical cancer, with elevated levels typically indicating a higher tumor burden. However, its prognostic value in cervical cancer patients remains debated.
Xiumin Zhao +4 more
doaj +1 more source
Favorable Long-Term Outcome in Male Breast Cancer
European Journal of Breast Health, 2018 Objective: Male breast cancer (MBC) is a rare type of cancer in the breast cancer series and in the male population. Data is usually extrapolated from female breast cancer (FBC) studies. We aim to study the clinicopathological characteristics and outcome
Enver Özkurt +7 more
doaj +1 more source
BMC Cancer, 2022 Objective This study was designed to investigate the frequency and clinicopathological characteristics of POLE-mutated/ultramutated (POLEmut) in endometrial carcinoma (EC) and assess the prognostic values of POLE status. Methods Electronic databases were
Qing Wu, Nianhai Zhang, Xianhe Xie
doaj +1 more source