Results 81 to 90 of about 10,714,680 (266)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
The Role of Complete Blood Count Parameters in Patients with Colorectal Cancer
Acta Clinica Croatica, 2018 Chronic inflammation has been linked with many cancers. It seems that easily available and usual blood inflammatory markers might serve as a prognostic factor for overall survival and disease-free survival in patients with various cancers.
Melih Solak Mekić +8 more
doaj +1 more source
, 2012 A. Results of the meta-analysis on overall survival at 3 years. B. Results of the meta-analysis on overall survival at 5 years. C. Results of the meta-analysis on disease-free survival at 3 years. D.
Mingzhe Weng (132949) +7 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Thoracic CancerBackground The prognostic significance of EGFR mutations in resected non‐small cell lung cancer (NSCLC) remains uncertain despite their established predictive value in advanced disease.
Soo Han Kim +10 more
doaj +1 more source
Comparison of disease-free survival according to USP22.
, 2013 A) Disease-free survival curves of all OSCC patients.
Yao Sun (145327) +6 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2013 Disease free survival curves showing biotinidase expression in (a) nucleus [median disease-free survival 116 months]; (b) cytoplasm [median disease-free survival 111 months]; (c) and overall (nucleus and cytoplasm) [median disease-free survival 109 ...
Jatinder Kaur (236373) +6 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source