Results 121 to 130 of about 10,094,215 (299)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Diagnostic criteria for Menière's disease

, 2015
José A. López‐Escámez, John P. Carey, Won-Ho Chung, Joel A. Goebel, Måns Magnusson, Marco Mandalà, David E. Newman‐Toker, Michael Strupp, Mamoru Suzuki, Franco Trabalzini, Alexandre Bisdorff   +10 more
openalex   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Trends in the epidemiology of cardiovascular disease in the UK [PDF]

, 2016
Prachi Bhatnagar, Kremlin Wickramasinghe, Elizabeth Wilkins, Nick Townsend   +3 more
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer [PDF]

, 2021
Kristiina Rajamäki, Aurora Taira, Riku Katainen, Niko Välimäki, Anna Kuosmanen, Roosa-Maria Plaketti, Toni T. Seppälä, Maarit Ahtiainen, Erkki‐Ville Wirta, Emilia Vartiainen, Päivi Sulo, Janne Ravantti, Suvi Lehtipuro, Kirsi J. Granberg, Matti Nykter, Tomas Tanskanen, Ari Ristimäki, Selja Koskensalo, Laura Renkonen‐Sinisalo, Anna Lepistö, Jan Böhm, Jussi Taipale, Jukka‐Pekka Mecklin, Mervi Aavikko, Kimmo Palin, Lauri A. Aaltonen   +25 more
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

REPRESENTACIONES SOCIALES DE SALUD Y ENFERMEDAD: INVESTIGANDO EL ESTADO DEL ARTE

Ciencia y Enfermería
Investigación documental de carácter retrospectivo, que tiene como objetivo identificar el estado actual del arte en relación con la producción académica referente a la salud y la enfermedad, desde la perspectiva de las representaciones sociales.
DANIEL GONZALO ESLAVA ALBARRACÍN, MARIA CECÍLIA PUNTEL DE ALMEIDA   +1 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The role of estrogen and androgen receptors in bone health and disease

, 2013
Stavros C. Manolagas, Charles A. O’Brien, Maria Almeida   +2 more
openalex   +2 more sources