Results 131 to 140 of about 27,443,428 (376)

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

open access: yesFEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio   +9 more
wiley   +1 more source

Ranking and Clustering Iranian Provinces Based on COVID-19 Spread: K-Means Cluster Analysis

open access: yesJournal of Environmental Health and Sustainable Development, 2021
Introduction: The Coronavirus has crossed geographical borders. This study was performed to rank and cluster Iranian provinces based on coronavirus disease (COVID-19) recorded cases from February 19 to March 22, 2020.
Farzan Madadizadeh, Reyhane Sefidkar
doaj  

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Studi Fenomenologi Perawat Dalam Merawat Anak Dengan Penyakit Kawasaki Di Rumah Sakit Palembang [PDF]

open access: yes, 2017
Kawasaki disease is a disease which the etiology is not known clearly and can attacks the coronary arteries of infants and children. In Indonesia, Kawasaki disease is occour rarely, the lack of information relating to this disease, especially treatment ...
Sugiharti, Yohana
core  

O doente de hanseníase em Campinas: uma perspectiva antropológica

open access: yesCadernos de Saúde Pública
Este artigo estuda a experiência de vida de doentes e comunicantes de hanseníase em Campinas, Brasil, a partir da análise de suas representações sobre saúde, doença e terapêutica.
Marcos S. Queiroz   +1 more
doaj  

A saúde e sua relação intrínseca com o organismo e o ambiente

open access: yesForum Sociológico, 2010
O ambiente influencia a saúde de variadas maneiras: através da exposição a factores de risco físicos, químicos e biológicos, e através de alterações relacionadas com o comportamento dos indivíduos em resposta aos mesmos factores.
Inês Meira, Ana Patrícia Carvalho
doaj   +1 more source

Paget’s disease

open access: yesReumatismo, 2014
Paget’s disease of bone is the most common metabolic bone disease after osteoporosis and affects 2-4% of adults over 55 years of age. Its etiology is only partly understood and includes both genetic and environmental factors. The disease may be asymptomatic and can be uncovered incidentally on x-ray or in biochemical tests performed for another ...
Bertoldi, I.   +3 more
openaire   +8 more sources

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

open access: yesFEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran   +6 more
wiley   +1 more source

On Diseases of the Skin [PDF]

open access: yesThe American Journal of the Medical Sciences
6th American from the fifth and revised London edition. ; xix, [33]-694 p.
openaire   +3 more sources

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