Results 141 to 150 of about 27,151,543 (398)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Endothelial dysfunction in adolescents and young adults with nonalcoholic liver disease [PDF]

, 2019
Nonalcoholic liver disease is a global public health problem that increases cardiovascular morbidity and mortality in these patients. This paper discusses endothelial dysfunction among patients (adolescents and young adults) with nonalcoholic liver ...
Donoiu, Ionuț, Istrătoaie, Octavian, Moise, Cristiana G, Mustafa, Edme R, Rogoveanu, Ion, Tudorașcu, Diana R, TÂRTEA, Georgică C   +6 more
core   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Studi Fenomenologi Perawat Dalam Merawat Anak Dengan Penyakit Kawasaki Di Rumah Sakit Palembang [PDF]

, 2017
Kawasaki disease is a disease which the etiology is not known clearly and can attacks the coronary arteries of infants and children. In Indonesia, Kawasaki disease is occour rarely, the lack of information relating to this disease, especially treatment ...
Sugiharti, Yohana
core  

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Lectures on the Pathology, Diagnosis, and Treatment of Bright's Disease [PDF]

, 1873
G. Allan Johnson
  +6 more sources

Social Acceptance for Patients with Pulmonary Tuberculosis from Their Own Perspective in Rafsanjan, Iran: A Cross Sectional Study

Journal of Community Health Research, 2022
Introduction: Social acceptance is defined as the support by social network for patients via family, friends and colleagues that often reason the better management and prognosis.
Rzea Bidaki, Marzie Bagheri Mahonaki, Ziba Shabani Shahrbabaki, Hamid Bakhshi Aliabad, Maryam Sadeh   +4 more
doaj  

Dynamic of Vascular Streak Dieback Disease Incidence on Susceptible Cacao Treated with Composted Plant Residues and Trichoderma asperellum in Field

Agronomy, 2019
Trichoderma asperellum, composted plant residues, and its combination can control vascular-streak dieback (VSD) disease caused by fungus Ceratobasidium theobromae in laboratory conditions. In this trial, we evaluated these treatments in two years through
Ade Rosmana, Muhammad Taufik, Asman Asman, Nurul Jihad Jayanti, Andi Akbar Hakkar   +4 more
doaj   +1 more source