Results 191 to 200 of about 12,631,953 (278)

Inflammatory Bowel Disease in Kazakhstan: Phenotypes, Disease Activity, and Treatment Patterns from a National Registry. [PDF]

J Clin Med
Kaibullayeva J, Ualiyeva A, Tanabayeva A, Nauryzbayeva A, Kabdulina N, Agzamova Z, Gladysheva Y, Yeskozhina A, Mussatayev I, Doszhan A, Kurmangaliyeva A, Kenzhebayeva E, Kushimova D, Laryushina Y, Temirbayev Z, Rayushkina L, Izenova M, Smagulova Z, Chalabayeva A, Dossanova R, Adayeva D, Muldasheva P, Atasheva R, Kravtsova Y, Kuldeyev S, Shchukina O.   +25 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Noncommunicable diseases and dental diseases

Indian Journal of Dental Research, 2018
openaire   +3 more sources

Leucine-rich alpha-2 glycoprotein as a predictor of primary non-response to anti-TNF-α therapy in biologic-naïve Egyptian IBD patients. [PDF]

BMC Gastroenterol
Amer I, El Batae H, Elshaer YA, Sherief DE, Elkerdawy MA, Emara MH, El Sharawy S.   +6 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Short-term heart rate variability is preserved in Parkinson's disease under atomoxetine. [PDF]

Brain Commun
Orlando IF, Hezemans FH, Tsvetanov KA, Ye R, Rua C, Regenthal R, Barker RA, Williams-Gray CH, Passamonti L, Robbins TW, Rowe JB, O'Callaghan C.   +11 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Oral and Periodontal Manifestations in Systemic Sclerosis: A Comprehensive Review of Pathophysiology, Clinical Features, and Management Strategies. [PDF]

Oral Health Prev Dent
Meer R.
europepmc   +1 more source