Results 1 to 10 of about 15,873,849 (315)

Inflammasome Activation in Parkinson’s Disease

Journal of Parkinson's Disease, 2022
Chronic sterile inflammation and persistent immune activation is a prominent pathological feature of Parkinson’s disease (PD). Inflammasomes are multi-protein intracellular signaling complexes which orchestrate inflammatory responses in immune cells to a diverse range of pathogens and host-derived signals.
Jewell, Shannon, Herath, Ashane M., Gordon, Richard   +2 more
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The Assessment of Disease Activity in Rheumatic Diseases [PDF]

International Journal of Rheumatology, 2013
Disease activity in the rheumatic diseases can be defined as a reversible state, manifested by clinical, laboratory, or radiographical features. Disease activity occurs principally as a result of immunologic and inflammatory processes involving specific organs at a specific point in time.
Thurayya Arayssi, Zahi Touma, Mandana Nikpour, Lilian Ghandour   +3 more
openaire   +3 more sources

The Behcet's Disease Activity Index [PDF]

Rheumatology, 2004
To identify a subset of clinical features of Behçet's disease (BD) that can be summated to form an overall index of disease activity appropriate for clinical and research use internationally.Completed Behçet's Disease Current Activity Forms were collected from a total of 524 patients with BD from five countries.
G, Lawton, M A, Chamberlain, B B, Bhakta, A, Tennant   +3 more
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Association of Periodontal Disease with Activity of Crohn's Disease

Medicina, 2023
Introduction: Crohn's disease (CD) is a chronic inflammatory granulomatous disease that can affect the entire gastrointestinal tract. It is characterized by various extraintestinal manifestations (EIM), of which oral manifestations (OM) are often possible.
Miloš Živić, Nebojsa Zdravkovic, Bojan Stojanovic, Bojan Milosevic, Zeljko Todorovic, Miljan Adamović, Natasa Zdravkovic   +6 more
openaire   +3 more sources

MONOCYTE ACTIVITY IN BEHÇET'S DISEASE [PDF]

Rheumatology, 1996
Monocytes obtained from patients with Behçet's disease (BD) were examined for differentiation markers (expression of CD14 and antigens reacting with monoclonal antibodies 25F9 and G16/1) and for expression of selected adhesion molecules. There was significantly raised expression of the CD14 molecule, and increased staining with 25F9 and G16/1 ...
Sahin, S, Lawrence, R, Direskeneli, H, Hamuryudan, V, Yazici, H, Akoglu, T   +5 more
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Predicting Endoscopic Disease Activity in Crohnʼs Disease [PDF]

Inflammatory Bowel Diseases, 2015
Mucosal healing is presently considered one of the primary goals in treatment of Crohn's disease (CD), but this can only be confirmed by endoscopy. We aimed to design and validate a new disease activity index based on a combination of clinical characteristics and readily available laboratory parameters, which reliably predicts the presence and severity
Minderhoud, I.M., Steyerberg, E.W., van Bodegraven, A.A., van der Woude, C.J., Hommes, D.W., Dijkstra, G., Fidder, H.H., Schwartz, M.P., Oldenburg, B.   +8 more
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Disease Activity Measures in Paediatric Rheumatic Diseases [PDF]

International Journal of Rheumatology, 2013
Disease activity refers to potentially reversible aspects of a disease. Measurement of disease activity in paediatric rheumatic diseases is a critical component of patient care and clinical research. Disease activity measures are developed systematically, often involving consensus methods.
Luca, Nadia J., Feldman, Brian M.
openaire   +3 more sources

Endoscopic Disease Activity in Inflammatory Bowel Disease [PDF]

Current Gastroenterology Reports, 2015
Endoscopic scoring systems in Crohn's disease and ulcerative colitis aim to translate the assessment of mucosal disease activity into a quantified value. This value seeks to provide a clear, objective record of the endoscopic mucosal severity, which can then be used to guide medical management decisions.
Ket, Shara Nguyen, Palmer, Rebecca, Travis, Simon   +2 more
openaire   +2 more sources

Measures of disease activity in glaucoma

Biosensors and Bioelectronics, 2022
Glaucoma is the leading cause of irreversible blindness globally which significantly affects the quality of life and has a substantial economic impact. Effective detective methods are necessary to identify glaucoma as early as possible. Regular eye examinations are important for detecting the disease early and preventing deterioration of vision and ...
Yue Wu, Maja Szymanska, Yubing Hu, M. Ihsan Fazal, Nan Jiang, Ali K. Yetisen, M. Francesca Cordeiro   +6 more
openaire   +3 more sources

Parkinson's disease and CYP1A2 activity [PDF]

British Journal of Clinical Pharmacology, 2000
Aims MPTP, a neurotoxin which induces parkinsonism is partially metabolized by the enzyme CYP1A2. Smoking appears to protect against Parkinson's disease (PD) and cigarette smoke induces CYP1A2 activity. Thus, we investigated the hypothesis that idiopathic PD is associated with lower CYP1A2 activity using caffeine as a probe ...
J T, Forsyth, R A, Grünewald, A, Rostami-Hodjegan, M S, Lennard, H J, Sagar, G T, Tucker   +5 more
openaire   +2 more sources