Results 271 to 280 of about 5,766,482 (313)
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Natalizumab for Active Crohn's Disease
New England Journal of Medicine, 2003In chronic inflammatory conditions such as Crohn's disease, the migration of leukocytes from the circulation into the parenchyma and their activation within inflammatory sites are mediated in part by alpha4 integrins.We conducted a double-blind, placebo-controlled trial of the alpha4 integrin-specific humanized monoclonal antibody natalizumab in 248 ...
Subrata, Ghosh +9 more
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[Rheumatic diseases and work: Patient activity versus disease activity].
Acta reumatologica portuguesa, 2009Rheumatic diseases have a substantial impact on the patient but also on the work status and on a social-economical context. In Europe 25% of the cost of disease is related with rheumatic diseases. We are focusing more on disease activity as a clinical challenge but we have to consider that patient occupational activity is a main issue as a strategic ...
Luís, Cunha-Miranda, Teresa, Cristóvam
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Telomerase Activity in Hodgkin's Disease
Blood, 1998Telomere maintenance executed by the action of telomerase seems to be a prerequisite for immortalization. Telomerase is found in most cell lines and malignant tumors. A telomerase-independent mechanism for telomere maintenance in Hodgkin's disease has been proposed in the absence of detectable telomerase activity. In this study, telomerase activity was
K F, Norrback +4 more
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Coagulation activation in liver diseases
Thrombosis Research, 1991In liver disorders alterations of the coagulation system are mainly due to a reduced synthesis of coagulation proteins. In addition, an enhanced intravascular consumption of coagulation factors is discussed controversely in liver diseases. By measuring factor IXiAT- and TAT-complexes we tried to find out, whether coagulation activation in liver ...
B, Kemkes-Matthes +2 more
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Physical Activity and Cardiovascular Disease
Seminars in Vascular Medicine, 2002This review, based on prospective epidemiological studies, indicates the existence of a dose-response relationship between physical activity and coronary heart disease (CHD), which is linear at least up to a certain level of activity. Leisure time physical activity is associated with about a 30-50% reduction in risk of CHD.
S Goya, Wannamethee, A Gerald, Shaper
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Current opinion in dentistry, 1992
Periodontal disease activity is defined clinically by progressive loss of probing attachment and radiographically by progressive loss of alveolar bone. The natural history of periodontal disease was originally considered to be nearly continuous and slowly progressive.
I B, Lamster, S D, Karabin
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Periodontal disease activity is defined clinically by progressive loss of probing attachment and radiographically by progressive loss of alveolar bone. The natural history of periodontal disease was originally considered to be nearly continuous and slowly progressive.
I B, Lamster, S D, Karabin
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Microglial Activation in Alzheimers Disease
Current Alzheimer Research, 2009Alzheimer's disease (AD) is a devastating chronic neurodegenerative disease with currently no available disease modifying treatment. In recent years, the peptide amyloid-beta has been proposed as the major pathogenic force in the development and progression of AD. Microglia, the resident immune and phagocytic cells of the brain, are known to constantly
Johannes C M, Schlachetzki +1 more
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2016
Chapter 8 of Clinical Notes on Disorders of Childhood. In this chapter, Winnicott discusses the exclusion of the diagnosis of active heart disease. He states that a child with a normal life and a normal level of health enjoyment does not have active heart disease.
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Chapter 8 of Clinical Notes on Disorders of Childhood. In this chapter, Winnicott discusses the exclusion of the diagnosis of active heart disease. He states that a child with a normal life and a normal level of health enjoyment does not have active heart disease.
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Complement Activation in Renal Disease
Uremia Investigation, 1984Perturbation of the serum complement system in glomerulonephritis can be the result of classical pathway activation by immune complexes or of C3 activation by the C3-C5 convertase stabilized by the C3 nephritic factor. Low C3 levels can also be the result of diminished C3 synthesis and possibly, in certain circumstances, of C3 convertases deposited on ...
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