Results 271 to 280 of about 12,421,057 (398)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Migraine Disease Burden and Trends (1990-2021): A Multidimensional Comparative Analysis of China and Other G20 Countries. [PDF]

Brain Behav
Yang R, Chen W, Sun M, Feng H, Chen B, Luo X, Li Z, Qiao F, Tang H, Ren H.   +9 more
europepmc   +1 more source

The burden of ambient air pollution on years of life lost from ischaemic heart disease in Pudong New Area, Shanghai [PDF]

Xing Zhong, Yichen Chen, Lianghong Sun, Hua Chen, Xiaobing Qu, Lipeng Hao   +5 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

SAT-623 Regional Incidence and Prevalence of Type-1 Diabetes Mellitus among Adolescents and Young Adults (15-39) from 1990 to 2021: A Global Burden of Disease Study [PDF]

Husnain Ahmad, Mian Zahid Jan Kakakhel, Mohammad Aman Ullah, Muhammad Saeed, Jibran Ikram, Abdul Qadeer, Muneeb Khawar, Hamna Jawad, Sareer Haider, Rabbia Haider, Faizan Ahmed, Robert W. Kirchoff   +11 more
openalex   +1 more source

Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study

Circulation, 2014
S. Chugh, Rasmus J. Havmoeller, K. Narayanan, David Singh, M. Rienstra, E. Benjamin, R. Gillum, Young-Hoon Kim, J. Mcanulty, Zhi‐Jie Zheng, M. Forouzanfar, M. Naghavi, G. Mensah, M. Ezzati, C. Murray   +14 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Data Sheet 1_Socioeconomic drivers of encephalitis burden in the post-COVID era: a 204-country analysis from global burden of disease study 2021.pdf

Yikang Wang (2188945), Di Wang (329735), Yu Tian (367745), Yilong Yao (133693), Qi Yu (279662)   +4 more
openalex   +1 more source

Comments on “Impact of Neuropsychiatric Symptoms on Caregiver Burden in Major Neurocognitive Disorder due to Lewy Body Disease: A Bibliometric Analysis” [PDF]

Mohammad Idrees, Anfal Khan, Amin Ul Haq, Syed Rahman, Ameer Afzal Khan   +4 more
openalex   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source