Results 141 to 150 of about 7,932,688 (301)

2019 Chinese expert consensus statement on diagnosis and treatment of syphilis

Chinese Medical Journal, 2020
Li-Shao Guo, National Center for Sexually Transmitted Disease Control, China Centers for Disease Control and Prevention; Committee of Sexually Transmitted Disease, Branch of Dermatovenereology, Chinese Medical Association; Committee of Sexually Transmitted Disease, Branch of Dermatologists, Chinese Medical Doctor Association   +1 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Artificial intelligence for Africa: bridge or barrier for infectious disease control? [PDF]

IJID Reg
Branda F, Kapologwe NA.
europepmc   +1 more source

Modeling and Optimal Control Applied to a Vector Borne Disease

, 2012
A model with six mutually-exclusive compartments related to Dengue disease is presented. In this model there are three vector control tools: insecticides (larvicide and adulticide) and mechanical control.
Monteiro, M. Teresa T., Rodrigues, Helena Sofia, Torres, Delfim F. M.   +2 more
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Epilepsy in children: quality of life and disease control. [PDF]

Front Neurol
Almomani MA, Almomani BA, Banikhaled RB, Elayyan RN, Abu Abbas YH, Al Thiabat H, Al-Qudah H.   +6 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Machine Learning Used in Communicable Disease Control: A Scoping Review. [PDF]

Public Health Rev
Birdi S, Patel A, Rabet R, Singh N, Durant S, Vosoughi T, Kapra F, Shergill M, Mesfin E, Ziegler C, Ali S, Buckeridge D, Ghassemi M, Gibson J, John-Baptiste A, Macklin J, Mccradden M, Mckenzie K, Mishra S, Naraei P, Owusu-Bempah A, Rosella L, Shaw J, Upshur R, Pinto AD.   +24 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A bacterial nutrition strategy for plant disease control. [PDF]

Science
Wang S, Zhu L, Tian M, Wu W, Hu X, Li X, Wang J, Zhu Y, Xu J, Mou B, Yang J, Cui F, Li D, Cheng J, Liu Z, Wang MA, Qi L, Jin W, Luo ZQ, Zhou P, Lee YH, Staskawicz B, He SY, Sun W.   +23 more
europepmc   +1 more source