Results 211 to 220 of about 123,413 (291)

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Confirmation of Helicobacter pylori eradication using ¹³C urea breath test: addressing the regional post-treatment outcomes. [PDF]

BMC Gastroenterol
Muthuluru D, Patanik SB, Jeji PS, Dobhada A, Uthansingh K, Sahu MK.   +5 more
europepmc   +1 more source

Hookworm Disease or Uncinariasis: Its Symptoms, Prevalence, and Proposed Methods of Eradication.

, 1912
M H Boerner
openalex   +1 more source

Antibacterial Applications of Black and Violet Phosphorus‐Based Biomaterials

Advanced NanoBiomed Research, EarlyView.
Black and violet phosphorus‐based biomaterials exhibit broad‐spectrum antibacterial efficacy in various infections, including bone, skin, ocular, dental, lung, and sepsis cases. Their antibacterial mechanisms include physical disruption, light‐driven effects, targeted drug delivery, and enhanced composite strategies.
Zhuo Dai, Yu Zhang, Xiaoye Li, Ao He, Qiang Li, Weijun Xiu, Yongbin Mou, Heng Dong, Meng Ding   +8 more
wiley   +1 more source

Improving Helicobacter pylori Treatment Standards: A Quality Improvement Project Against Maastricht VI Guidelines. [PDF]

Cureus
Varier S, Mansingh M, Patel D, Desai B, Shah YM, Omar MA.   +5 more
europepmc   +1 more source

Comment on “Laparoscopic and Endoscopic Cooperative Surgery for Gastric Cancer as an Alternative Treatment in Elderly Patients: A Prospective Observational Study”

Annals of Gastroenterological Surgery, EarlyView.
Shyam Sundar Sah, Abhishek Kumbhalwar
wiley   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

<i>Helicobacter pylori</i> Eradication: Why Recurrence Risk Should Not Dictate Treatment Decisions. [PDF]

Ther Clin Risk Manag
Chen X, Wang Y, Dong Y, Yang J, Xie B, Zhang D.   +5 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Rebamipide as an Adjunctive Therapy for Gastrointestinal Diseases: An Umbrella Review. [PDF]

Pharmaceuticals (Basel)
Maev IV, Khurmatullina AR, Andreev DN, Zaborovsky AV, Kucheryavyy YA, Sokolov PS, Beliy PA.   +6 more
europepmc   +1 more source