Results 41 to 50 of about 5,208,080 (302)

Legionnaires' disease outbreak

Communicable Diseases Intelligence, 1998
Discusses an outbreak of Legionnaire's disease in Victoria, during June and July ...
openaire   +2 more sources

On the predictability of infectious disease outbreaks [PDF]

Nature Communications, 2019
AbstractInfectious disease outbreaks recapitulate biology: they emerge from the multi-level interaction of hosts, pathogens, and environment. Therefore, outbreak forecasting requires an integrative approach to modeling. While specific components of outbreaks are predictable, it remains unclear whether fundamental limits to outbreak prediction exist ...
Samuel V. Scarpino, Giovanni Petri
openaire   +4 more sources

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Strategies and Opportunities to Improve Community Health through Advanced Molecular Detection and Genomic Surveillance of Infectious Diseases

Emerging Infectious Diseases
Advanced molecular detection (AMD) refers to the integration of next-generation sequencing, epidemiologic, and bioinformatics data to drive public health actions.
Jazmyn Moore, Ruth Sanon, Yury Khudyakov, Nathelia Barnes   +3 more
doaj   +1 more source

Prototype Biodiversity Digital Twin: Disease Outbreaks [PDF]

Research Ideas and Outcomes
African swine fever is a transmissible virus impacting wild and domestic swine populations. In Europe, it is non-native and the recently introduced genotype affects wild boar populations with occasional outbreaks in domestic pigs.
Kate Ingenloff, Syrine Ben Aziza, Claus Weiland, Nikoletta Nikolova, Hans-Hermann Thulke, Martin Lange, Adam Reichold, Dmitry Schigel   +7 more
doaj   +3 more sources

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Strategies for controlling non-transmissible infection outbreaks using a large human movement data set [PDF]

, 2014
Prediction and control of the spread of infectious disease in human populations benefits greatly from our growing capacity to quantify human movement behavior.
House, Thomas A, Hancock, Penelope A., Matthew J Keeling, Ian M Hall, Rehman, Yasmin, Leon Danon, Ian M. Hall (265462), Leon Danon (365019), Hall, Ian M, House, Thomas A., Obaghe Edeghere, Hall, Ian; id_orcid, Matthew J. Keeling (628451), Penelope A. Hancock (223305), Thomas A. House (628450), Hancock, Penelope A, Penelope A Hancock, Obaghe Edeghere (628449), Yasmin Rehman (628448), Edeghere, Obaghe, Keeling, Matthew James, House, Thomas A; id_orcid, Keeling, Matthew J, Keeling, Matthew J., Hall, Ian M., Yasmin Rehman, Danon, Leon, Thomas A House   +27 more
core   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

Acute Conjunctivitis among Patients Visiting the Outpatient Department of Ophthalmology in a Tertiary Care Centre

Journal of Nepal Medical Association
Introduction: Conjunctivitis is a highly prevalent ocular disease that flares up every year. The humidity and high temperature favour the causative agents responsible for the epidemic.
Ram Shrestha, Roshija Khanal Rijal, Neyaz Kausar, Oshan Shrestha, Sagar Rajkarnikar, Raina Chaudhary, Kabindra Lal Shrestha, Sitaram Khadka   +7 more
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source