Results 161 to 170 of about 9,212,440 (297)

Internally displaced persons' ed utilization and disease patterns: A single center retrospective chart review. [PDF]

PLoS One
Hitti E, Chamandi G, Fadlallah H, Tamim H, Makki M, Mufarrij A.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Profiling Disease Patterns Using ICD-11 at a University Hospital in Ghana: A Retrospective Analysis of Cross-Sectional Data From 2018 to 2021. [PDF]

Health Sci Rep
Ampah BA, Opoku DA, Sackeya E, Ayisi-Boateng NK, Konadu E, Addae M, Tawiah P, Mensah KA.   +7 more
europepmc   +1 more source

Shifts in Chronic Disease Patterns Among Spanish Older Adults With Multimorbidity Between 2006 and 2017. [PDF]

Int J Public Health, 2023
Spijker JJA, Rentería E.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Hypergraph clustering for analyzing chronic disease patterns in mild cognitive impairment reversion and progression. [PDF]

Sci Rep
Garg M, Liu X, Jeon E, Vassilaki M, Petersen RC, Sauver JS, Sohn S.   +6 more
europepmc   +1 more source

Evaluating Disease Patterns of Military Working Dogs in the Republic of Korea: A Retrospective Study. [PDF]

Animals (Basel), 2023
Park S, Park G, Rieu MS, Kim T, Kim D, Lee S, Kim G.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Unveiling Food Avoidance Among Patients With Inflammatory Bowel Disease: Patterns and Pathways to Better Dietary Management. [PDF]

J Nurs Manag
Wang Q, Zhou M, Li S, Zickgraf HF, Yang J, Lei Y, Lin Z.   +6 more
europepmc   +1 more source

Disease patterns and specific trajectories of anti-MDA5-related disease: a multicentre retrospective study of 70 adult patients. [PDF]

Front Immunol, 2023
de Boysson H, Cuchet M, Cassius C, Cuchet P, Agard C, Audemard-Verger A, Marchand-Adam S, Cohen-Sors R, Gallay L, Graveleau J, Lesort C, Ly K, Meyer A, Monseau G, Néel A, Bonnotte B, Pérard L, Schleinitz N, Mariotte D, Le Mauff B, Bourdenet G, Masmoudi W, Deshayes S, Dumont A, Dompmartin A, Kottler D, Aouba A.   +26 more
europepmc   +1 more source