Results 211 to 220 of about 1,478,699 (259)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

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Lack of radiosensitivity predicts poor disease specific survival in myxoid liposarcoma

Journal of Surgical Oncology, 2022
AbstractBackgroundCompared to other sarcomas, myxoid liposarcoma (ML) is known to be radiosensitive, with improved oncologic outcomes. Although these tumors “shrink” following radiotherapy, there is a paucity of data examining the degree of radiosensitivity and oncologic outcome.
Matthew T. Houdek, Katherine E. Mallett, Mark J. Heidenreich, Safia K. Ahmed, Doris E. Wenger, John‐Rudolph H. Smith, Brittany L. Siontis, Steven I. Robinson, Andrew L. Folpe, Ivy A. Petersen, Peter S. Rose   +10 more
openaire   +2 more sources

Disease-Specific Survival in Patient-Detected Breast Cancer

Clinical Breast Cancer, 2006
Patient-detected breast cancer is not well described, and its association with survival is not known.Initial breast cancer detection methods were extracted from patient chart notes in a registry cohort of women aged 40-93 with primary invasive breast cancer seen at the community-based regional cancer center between 1990 and 1999 (N = 2228).
Henry G, Kaplan, Judith A, Malmgren
openaire   +2 more sources

Atypical meningioma. A study on recurrence and disease-specific survival

Neurochirurgie, 2017
To analyse the outcome of patients with WHO grade II meningioma and identify factors that may influence recurrence and survival.Between January 2000 and October 2016, a retrospective search identified 215 WHO grade II meningiomas operated on at our institution. A survival analysis was conducted on clinical and histological criteria.Eighteen patients (8.
C, Champeaux, D, Houston, L, Dunn
openaire   +2 more sources

Increasing tumor budding in cholangiocarcinoma is associated with decreased disease-specific survival

Human Pathology, 2021
Tumor budding (TB) has been shown to be an adverse prognostic factor in several gastrointestinal malignancies, most notably colorectal carcinoma (CRC). TB has undergone some evaluation in Eastern cohorts of cholangiocarcinoma (CC), and we undertook this study to evaluate whether TB in CC was linked to other clinicopathologic factors or to outcome in a ...
Diana Agostini-Vulaj, Justin M.M. Cates, Laura E. Bratton, Raul S. Gonzalez   +3 more
openaire   +2 more sources

DISEASE-SPECIFIC SURVIVAL FOR A NEW T-STAGE OF OROPHARYNGEAL CANCER

British Journal of Oral and Maxillofacial Surgery, 2000
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CARINCI, Francesco, FARINA A, BOVICELLI A, PELUCCHI, Stefano, CALEARO C.   +4 more
openaire   +2 more sources