Results 61 to 70 of about 1,289,778 (299)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Disease Surveillance Networks Initiative Africa: Final Evaluation [PDF]

, 2011
The overall objective of the Foundation's Disease Surveillance Networks (DSN) Initiative is to strengthen technical capacity at the country level for disease surveillance and to bolster response to outbreaks through the sharing of technical information ...
Akaco Ekirapa, Barbara Matthys, Jakob Zinsstag, Lisa Crump, Nelly Yatich, Remare Ettarh   +5 more
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Alpha-fetoprotein detection of hepatocellular carcinoma leads to a standardized analysis of dynamic AFP to improve screening based detection [PDF]

, 2016
Detection of hepatocellular carcinoma (HCC) through screening can improve outcomes. However, HCC surveillance remains costly, cumbersome and suboptimal. We tested whether and how serum Alpha-Fetoprotein (AFP) should be used in HCC surveillance.
Ahn, Sang Hoon, Bird, Sheila M., Bird, Thomas G., Blunsum, Andrew, Cusack, Pearce, Dimitropoulou, Polyxeni, Hayes, Peter C., Hey, Shiying, Jenks, Sara J., Kelly, Sarah, Sturgeon, Catharine, Turner, Rebecca M.   +11 more
core   +4 more sources

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Disease surveillance [PDF]

Canadian Medical Association Journal, 2008
A. Attaran, P. C. Hebert
  +5 more sources

Systems approaches to animal disease surveillance and resource allocation: methodological frameworks for behavioral analysis [PDF]

, 2013
While demands for animal disease surveillance systems are growing, there has been little applied research that has examined the interactions between resource allocation, cost-effectiveness, and behavioral considerations of actors throughout the livestock
Denwood, M.J., Gunn, G.J., Mellor, D.J., Reid, S.W.J., Rich, K.M., Stott, A.W.   +5 more
core   +4 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Exploring pig trade patterns to inform the design of risk-based disease surveillance and control strategies [PDF]

, 2016
An understanding of the patterns of animal contact networks provides essential information for the design of risk-based animal disease surveillance and control strategies.
A Clauset, A Gillespie, A Ortiz-Pelaez, A Scott, A-L Barabási, AP Iannoni, AR Elbers, B Martínez-López, B Martínez‐López, B Martínez‐López, C Brakewood, C Dubé, C Dubé, C Mannion, C Zepeda, DJ Watts, DM Green, EM Fèvre, IZ Kiss, J Gibbens, J Lowe, J Verdasca, JE Dent, L Mansley, L Mur, L Ratananakorn, M Bigras-Poulin, M Carrieri, M Gilbert, M Nöremark, M Stevenson, MD Shirley, ME Newman, MM Mweu, P Pons, R Kao, R Lysons, R Smith, RR Kao, S Bansal, S Dorjee, S Rautureau, S Rautureau, S Ribbens, S Robinson, SP Borgatti, T Porphyre   +46 more
core   +3 more sources